ChemicalBook > CAS DataBase List > (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

Product Name
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate
CAS No.
156311-83-0
Chemical Name
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate
Synonyms
PYAOP;((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V);PyAOP Novabiochem;(7-Azabenzotriazol-1;PVP-VACOPOLYMERSERIES;(7-AZABENZOTRIAZOLE-1-YLOXY)TRIPYRROLIDI;(7-Azabenzotriazol-1-yloxy)tripyrrolidinophospho;(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphoni;3H-1,2,3-triazolo[4,5-b]pyridine phosphonium derivative;tripyrrolidin-1-yl(triazolo4,5-b]pyridin-3-yloxy)phosphanium
CBNumber
CB4221362
Molecular Formula
C17H27F6N7OP2
Formula Weight
521.39
MOL File
156311-83-0.mol
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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Property

Melting point:
163-168 °C(lit.)
RTECS 
TH3890000
storage temp. 
-20°C
solubility 
Soluble in water or 1% acetic acid
form 
Powder or Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble in water.
InChI
InChI=1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
InChIKey
CBZAHNDHLWAZQC-UHFFFAOYSA-N
SMILES
[P+5]([F-])([F-])([F-])([F-])([F-])[F-].[P+](N1CCCC1)(N1CCCC1)(N1CCCC1)ON1N=NC2C=CC=NC1=2
CAS DataBase Reference
156311-83-0(CAS DataBase Reference)
EPA Substance Registry System
Phosphorus(1+), [3-(hydroxy-.kappa.O)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) (156311-83-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.51221
Product name
PyAOP
Purity
Novabiochem?
Packaging
25g
Price
$201
Updated
2025/07/31
Sigma-Aldrich
Product number
8.51221
Product name
PyAOP
Purity
Novabiochem?
Packaging
100g
Price
$602
Updated
2025/07/31
Sigma-Aldrich
Product number
8.51221
Product name
PyAOP
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$4720
Updated
2025/07/31
Sigma-Aldrich
Product number
8.51221
Product name
PyAOP
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$4720
Updated
2025/07/31
Sigma-Aldrich
Product number
535303
Product name
(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity
96%
Packaging
1g
Price
$121
Updated
2025/07/31
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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Chemical Properties,Usage,Production

Chemical Properties

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is white to off-white crystalline powder

Uses

PyAOP is a phosphonium salt used as a coupling reagent in solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt (H805070).

Uses

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen.

reaction suitability

reaction type: Coupling Reactions

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Suppliers

Canada 1 China 222 Europe 1 Germany 3 India 4 Israel 1 Switzerland 2 United Kingdom 7 United States 19 Global 260
Luxembourg Bio Technologies
Tel
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Fax
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Email
yoav@luxembourg-bio.com
Country
Israel
ProdList
58
Advantage
58
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View Lastest Price from (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate 156311-83-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26
Anhuyan (Hainan) Biotechnology Co., LTD
Product
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate 156311-83-0
Price
US $0.00/G/KG
Min. Order
1G/KG
Purity
99%
Supply Ability
100000
Release date
2025-02-12
PNP Biotech Co. Ltd
Product
PyAOP 156311-83-0
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2022-09-16

156311-83-0, (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphateRelated Search:

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate CHLOROPHOSPHONAZO III Polyvinylpyrrolidone N-Methyl-2-pyrrolidone Lithium hexafluorophosphate METHYL-2-PYRROLIDONE TRIS(DIETHYLAMINO)PHOSPHINE 7-Azabenzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate HOAt Hexafluorophosphoric acid PVP-VACOPOLYMERSERIES 1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphonium hexafluorophosphate(PyAOP)
  • ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V)
  • PyAOP (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphoniuM hexafluorophosphate
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinyl-phosphorus hexafluorophosphate
  • tris(pyrrolidin-1-yl)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})phosphanium
  • (7Azabenzotriazol1yloxy)tripyrrolidinophosphonium hexafluophosphate
  • (7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluoropho sphate, 99+% white crystalline powder
  • ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexa
  • tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphonium
  • tris(1-pyrrolidinyl)-(3-triazolo[4,5-b]pyridinyloxy)phosphonium hexafluorophosphate
  • (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate 96%
  • PYAOP
  • ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphat
  • 7-Azabenzotriazol-1-yloxy)tripyrrolidino-phosphonium hexafluorophosphate≥ 99% (HPLC)
  • PyAOP Novabiochem
  • (7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate
  • (7-AZABENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE
  • 7-AZABENZOTRIAZOL-1-YLOXY-TRIS-(PYRROLIDINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE
  • (7-AZABENZOTRIAZOLE-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate
  • (7-AZABENZOTRIAZOLE-1-YLOXY)TRIPYRROLIDI
  • (7-Azabenzotriazol-1-yloxy)tripyrrolidinophospho
  • PY (7-AZABENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
  • PYAOP ((7-AZABENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE)
  • 3H-1,2,3-triazolo[4,5-b]pyridine phosphonium derivative
  • (7-Azabenzotriazol-1
  • (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphoni
  • PVP-VACOPOLYMERSERIES
  • (7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphoniuM hexafluorophosphate, 99+%
  • Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)
  • Tripyrrolidin-1-yl(triazolo4,5-bpyridin-3-yloxy)phosphonium hexafluorophosphate
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate USP/EP/BP
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrol...
  • tripyrrolidin-1-yl(triazolo4,5-b]pyridin-3-yloxy)phosphanium
  • (T-4)-[3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-) (1:1)
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphoniumhex
  • (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, PyAOP
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate，98%
  • (T-4)-[3-(Hydroxy-kappao)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-pyrrolidin-1-yl-phosphorus(I) hexafluorophosphate(I)
  • 156311-83-0
  • C17H27N7OPPF6
  • C17H27F6N7OP2
  • Coupling
  • Synthetic Reagents
  • Phosphonium/Uronium/Formamidinium
  • Coupling Reagent