1-Methyl-1H-1,2,4-triazol-3-amine

Product Name: 1-Methyl-1H-1,2,4-triazol-3-amine
CAS No.: 49607-51-4
Chemical Name: 1-Methyl-1H-1,2,4-triazol-3-amine
Synonyms: 1-methyl-1,2,4-triazol-3-amine;3-Amino-1-methyl-1,2,4-triazole;1-Methyl-1H-1,2,4-triazol-3-amine;3-Amino-1-methyl-1H-1,2,4-triazole;1H-1,2,4-Triazol-3-amine, 1-methyl-;1-methyl-1H-1,2,4-triazol-3-amine(SALTDATA: HCl)
CBNumber: CB42227096
Molecular Formula: C3H6N4
Formula Weight: 98.11
MOL File: 49607-51-4.mol

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1-Methyl-1H-1,2,4-triazol-3-amine Property

Melting point:: 81-86℃
Boiling point:: 281.9±23.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 5.15±0.10(Predicted)
color: Pale Yellow to Light Yellow

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: M218815
Product name: 1-Methyl-1h-1,2,4-triazol-3-amine
Packaging: 500mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: 6721AB
Product name: 1-Methyl-1H-1,2,4-triazol-3-amine
Packaging: 1g
Price: $239
Updated: 2021/12/16

Ark Pharm

Product number: P000133507
Product name: 1-Methyl-1H-1,2,4-triazol-3-amine
Purity: 97+%
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: P000133507
Product name: 1-Methyl-1H-1,2,4-triazol-3-amine
Purity: 97+%
Packaging: 250mg
Price: $62
Updated: 2021/12/16

Ark Pharm

Product number: P000133507
Product name: 1-Methyl-1H-1,2,4-triazol-3-amine
Purity: 97+%
Packaging: 5g
Price: $477
Updated: 2021/12/16

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1-Methyl-1H-1,2,4-triazol-3-amine Chemical Properties,Usage,Production

Uses

N2-Methylpyridine-2,3-diamine is a useful reagent in synthesis of imidazopyridines, which show tuberculostatic activity.

Synthesis

26621-45-4

49607-51-4

General procedure for the synthesis of 1-methyl-1H-1,2,4-triazol-3-amine from 1-methyl-3-nitro-1H-1,2,4-triazole: Example H; 1-methyl-1H-[1,2,4]triazol-3-ylamine; 1-methyl-3-nitro-1H-1,2,4-triazole (613 mg, 4.8 mmol) synthesized according to the method described by R.W. Middleton et al. (Synthesis 1984, 740-3) was dissolved in 6 mL of methanol. 10% palladium carbon catalyst (51 mg) and hydrazine monohydrate (543 mg, 11 mmol) were added. The reaction mixture was refluxed for 1.5 hours. Upon completion of the reaction, the palladium carbon was removed by filtration and the catalyst was washed with methanol. The solvent was evaporated to afford 1-methyl-1H-1,2,4-triazol-3-amine (469 mg, 99% yield) as a white solid.

References

[1] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 55
[2] Patent: JP5829520, 2015, B2. Location in patent: Paragraph 0498
[3] Journal of the American Chemical Society, 2017, vol. 139, # 3, p. 1261 - 1274
[4] Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 10, p. 1935 - 1940
[5] Zhurnal Organicheskoi Khimii, 1988, vol. 24, # 10, p. 2145 - 2151

1-Methyl-1H-1,2,4-triazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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49607-51-4