5-BROMO-3-CHLORO-2-FORMYLPYRIDINE
- Product Name
- 5-BROMO-3-CHLORO-2-FORMYLPYRIDINE
- CAS No.
- 885168-04-7
- Chemical Name
- 5-BROMO-3-CHLORO-2-FORMYLPYRIDINE
- Synonyms
- KML-125;5-Bromo-3-chloropicolinaldehyde;5-BROMO-3-CHLORO-2-FORMYLPYRIDINE;5-bromo-3-chloropyridine-2-carbaldehyde;2-Pyridinecarboxaldehyde, 5-bromo-3-chloro-
- CBNumber
- CB4225173
- Molecular Formula
- C6H3BrClNO
- Formula Weight
- 220.45
- MOL File
- Mol file
5-BROMO-3-CHLORO-2-FORMYLPYRIDINE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to green yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B993980
- Product name
- 5-Bromo-3-chloropicolinaldehyde
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 8866BB
- Product name
- 5-Bromo-3-chloropicolinaldehyde
- Packaging
- 100mg
- Price
- $342
- Updated
- 2021/12/16
- Product number
- 8866BB
- Product name
- 5-Bromo-3-chloropicolinaldehyde
- Packaging
- 250mg
- Price
- $372
- Updated
- 2021/12/16
- Product number
- HCH0355437
- Product name
- 5-BROMO-3-CHLORO-2-FORMYLPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.47
- Updated
- 2021/12/16
- Product number
- A193811
- Product name
- 5-Bromo-3-chloropicolinaldehyde
- Purity
- 95%
- Packaging
- 5g
- Price
- $570
- Updated
- 2021/12/16
5-BROMO-3-CHLORO-2-FORMYLPYRIDINE Chemical Properties,Usage,Production
Synthesis
1383001-27-1
885168-04-7
To a solution of 5-bromo-3-chloro-N-methoxy-N-methylpyridinamide (9.0 g, 32.3 mmol, 1.0 equiv) in tetrahydrofuran (THF, 100 mL) was slowly added lithium aluminum hydride (LAH, 1 M in THF, 16.12 mL, 16.1 mmol, 0.5 equiv) at -70 °C. The reaction was continued at this temperature for 2 hours. Upon completion of the reaction (monitored by thin layer chromatography TLC), the reaction mixture was quenched with saturated sodium bicarbonate (NaHCO3) solution. Subsequently, it was extracted with ethyl acetate (EtOAc, 3 x 250 mL), the organic layers were combined and washed sequentially with distilled water (500 mL) and saturated saline (500 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by rapid column chromatography (CC) to afford 5-bromo-3-chloropyridin-2-aldehyde (5.0 g, 71% yield) as a brown gel.
References
[1] Patent: WO2015/158427, 2015, A1. Location in patent: Page/Page column 68
[2] Patent: WO2012/81736, 2012, A1. Location in patent: Page/Page column 102-103
5-BROMO-3-CHLORO-2-FORMYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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