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Pyridomycin

Product Name
Pyridomycin
CAS No.
18791-21-4
Chemical Name
Pyridomycin
Synonyms
Pyridomycin;3-Hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridylmethyl)-1,4-dioxa-8-azacyclododeca-6-yl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, 3-hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-
CBNumber
CB42282882
Molecular Formula
C27H32N4O8
Formula Weight
540.57
MOL File
18791-21-4.mol
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Pyridomycin Property

Melting point:
222°
Boiling point:
616.01°C (rough estimate)
Density 
1.3105 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Store at -20°C
solubility 
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
pka
11.54±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17095
Product name
Pyridomycin
Purity
≥95%
Packaging
500μg
Price
$364
Updated
2024/03/01
Cayman Chemical
Product number
17095
Product name
Pyridomycin
Purity
≥95%
Packaging
2.5mg
Price
$1181
Updated
2024/03/01
TRC
Product number
P997218
Product name
Pyridomycin
Packaging
1000μg
Price
$395
Updated
2021/12/16
TRC
Product number
P997218
Product name
Pyridomycin
Packaging
500μg
Price
$245
Updated
2021/12/16
Adipogen Life Sciences
Product number
BVT-0455-M001
Product name
Pyridomycin
Purity
≥98%(1H-NMR,HPLC)
Packaging
1mg
Price
$290
Updated
2021/12/16
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Pyridomycin Chemical Properties,Usage,Production

Description

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml).

Uses

Pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under several names. The unusual 12-membered macrocyclic depsipeptide comprises three unique sub-units incorporating two substituted pyridines. Pyridomycin is thought to target NADH-dependent enoyl (acyl-carrier-protein) reductase InhA. Recent reports of activity against isoniazid-resistant mycobacteria has seen pyridomycin identified as a potential lead for new generation antibiotics.

Uses

Pyridomycin is a potent antibiotic active against mycobacteria.

Pyridomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridomycin Suppliers

Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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China
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Lynnchem
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86-(0)29-85992781 17792393971
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Nanjing Shizhou Biology Technology Co.,Ltd
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Henan Tianfu Chemical Co.,Ltd.
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18791-21-4, PyridomycinRelated Search:


  • 3-Hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridylmethyl)-1,4-dioxa-8-azacyclododeca-6-yl]-2-pyridinecarboxamide
  • Pyridomycin
  • 2-Pyridinecarboxamide, 3-hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-
  • 18791-21-4
  • C27H32N4O8