1-PYRIDIN-3-YL-ETHYLAMINE

1-PYRIDIN-3-YL-ETHYLAMINE Property

Melting point:

63 °C

Boiling point:

118-120 °C(Press: 14 Torr)

Density 

1.014 g/cm3(Temp: 25 °C)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.81±0.29(Predicted)

form 

liquid

color 

Colourless

Sensitive 

Air Sensitive

CAS DataBase Reference

56129-55-6(CAS DataBase Reference)

Safety

Hazard Codes 

T,Xi

Risk Statements 

25-41-43-37/38

Safety Statements 

26-36/37/39-45-39

RIDADR 

UN2735

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-PYRIDIN-3-YL-ETHYLAMINE Chemical Properties,Usage,Production

Uses

1-pyridin-3-ylethanamine is mainly used in scientific research experiments.

Synthesis

General procedure for the synthesis of 1-(3-pyridyl)ethylamine from 3-acetylpyridine: 1. 3-Acetylpyridine (0.5 g, 4.1 mmol), potassium carbonate (1.7 g, 12.3 mmol), hydroxylamine hydrochloride (342 mg, 5 mmol), and methanol (10 mL) were mixed and the reaction was stirred for 16 hours at room temperature. 2. After completion of the reaction, the mixture was filtered and the filtrate was collected. 3. Zinc powder (1.3 g, 21 mmol) and ammonium chloride (1.1 g, 21 mmol) were added to the filtrate and stirring was continued at room temperature for 24 hours. 4. At the end of the reaction, water (10 mL) was added to the reaction mixture and filtered again. 5. The filtrate was concentrated and dried to give the white solid product 1-(3-pyridyl)ethylamine in 300 mg yield and 60% yield. Product characterization data: 1H NMR (300 MHz, DMSO-d6) δ 8.52 (d, J = 4.9 Hz, 1H), 8.32 (td, J = 7.7, 1.9 Hz, 1H), 7.68 (d, J = 7.7 Hz, 1H), 7.28 (ddd, J = 7.5, 4.9, 1.1 Hz, 1H), 4.6 (q, J = 6.0 Hz, 1H) , 1.25 (d, J = 6.6 Hz, 3H); MS (ESI) m/z 123.4 [M + 1]+.

References

[1] Patent: WO2008/51493, 2008, A2. Location in patent: Page/Page column 105
[2] Patent: WO2003/99776, 2003, A1. Location in patent: Page 94-95
[3] Journal of the American Chemical Society, 1944, vol. 66, p. 1293
[4] Patent: WO2006/110668, 2006, A1. Location in patent: Page/Page column 54
[5] Patent: WO2009/42694, 2009, A1. Location in patent: Page/Page column 66