ChemicalBook > CAS DataBase List > (R,S)-ANATABINE

(R,S)-ANATABINE

Product Name
(R,S)-ANATABINE
CAS No.
2743-90-0
Chemical Name
(R,S)-ANATABINE
Synonyms
D,L-ANATABINE;rac-Anatabine;(R,S)-ANATABINE;Nicotine USP RC A;ANATABINE, (+/-)-(RG);Nicotine Impurity A as Racemate;1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE;Nicotine EP Impurity A as Racemate;1,2,3,6-Tetrahydro-2,3'-bipyridine;Anatabine, froM Nicotiana tabacuM L.
CBNumber
CB1382628
Molecular Formula
C10H12N2
Formula Weight
160.22
MOL File
2743-90-0.mol
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(R,S)-ANATABINE Property

Boiling point:
136
Density 
1.045±0.06 g/cm3(Predicted)
storage temp. 
Amber Vial, Refrigerator, Under Inert Atmosphere
solubility 
≤15mg/ml in DMSO;15mg/ml in dimethyl formamide
form 
solution in ethanol.
pka
8.84±0.40(Predicted)
color 
Light yellow to yellow
Stability:
Hygroscopic, Light Sensitive
CAS DataBase Reference
2743-90-0
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Safety

Risk Statements 
25-36
Safety Statements 
24/25
RIDADR 
2810
HazardClass 
IRRITANT
HS Code 
29399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3060
Product name
Nicotine Related Compound A/EP Impurity A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$576
Updated
2024/03/01
Sigma-Aldrich
Product number
1463326
Product name
Nicotine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$1380
Updated
2024/03/01
Cayman Chemical
Product number
11001
Product name
(R,S)-Anatabine
Purity
≥95%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
11001
Product name
(R,S)-Anatabine
Purity
≥95%
Packaging
10mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
11001
Product name
(R,S)-Anatabine
Purity
≥95%
Packaging
50mg
Price
$241
Updated
2024/03/01
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(R,S)-ANATABINE Chemical Properties,Usage,Production

Description

(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.

Chemical Properties

Light Yellow Oil

Uses

A nicotine metabolite

Uses

A nicotine (N412420) metabolite.

Uses

(R,S)-Anatabine is a metabolite of Nicotine (N412420).

in vitro

anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1].

in vivo

in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1].

References

[1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391.

(R,S)-ANATABINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R,S)-ANATABINE Suppliers

Shanghai Chenghe Medical Technology Co. Ltd.
Tel
18601603956
Email
18601603956@163.com
Country
China
ProdList
1118
Advantage
58
Jiangxi Kaixin Biomedical Co., Ltd.
Tel
0797-2111676 18890136722
Email
sales@chiralsyn.com
Country
China
ProdList
109
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
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View Lastest Price from (R,S)-ANATABINE manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
(R,S)-ANATABINE 2743-90-0
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-20

2743-90-0, (R,S)-ANATABINERelated Search:


  • (R,S)-ANATABINE
  • ANATABINE, (+/-)-(RG)
  • (+/-)-Anatabine, 3-(1,2,3,6-Tetrahydropyridin-2-yl)pyridine, 2-(Pyridin-3-yl)-1,2,3,6-tetrahydropyridine
  • Anatabine, froM Nicotiana tabacuM L.
  • D,L-ANATABINE
  • 1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE
  • Anatabine, 97%, from Nicotiana tabacum L.
  • 1,2,3,6-Tetrahydro-2,3'-bipyridine 98%
  • Nicotine USP RC A
  • 1,2,3,6-tetrahydro-2,3'-bipyridine dihydrochloride
  • Nicotine USP Related Compound A (rac-Nicotine EP Impurity A)
  • 2,3'-Bipyridine, 1,2,3,6-tetrahydro-
  • (R,S)Anatabine,inhibit,(R,S)-Anatabine,(R,S) Anatabine,Inhibitor
  • Nicotine Impurity A as Racemate
  • rac-Anatabine
  • Nicotine EP Impurity A as Racemate
  • 1,2,3,6-Tetrahydro-2,3'-bipyridine
  • (R,S)-Anatabine 100μg/mL in Methanol
  • 2743-90-0
  • 27430-90-0
  • Aromatics
  • Heterocycles
  • Metabolites & Impurities
  • Metabolites
  • Nicotine Derivatives