Neotuberostemonine

Product Name: Neotuberostemonine
CAS No.: 143120-46-1
Chemical Name: Neotuberostemonine
Synonyms: Neotuberostemonine;Neotuberostemonine, 10 mM in DMSO;(2S,31R,7aR,8R,8aR,11S,11aR,11bS)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one;(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4 -methyl-5-oxotetrahydro-2-furanyl]dodecahydroazepino[3,2,1-hi]fur o[3,2-e]indol-10(2H)-one;Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one,8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-,(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-
CBNumber: CB62519896
Molecular Formula: C22H33NO4
Formula Weight: 375.5
MOL File: 143120-46-1.mol

More

Less

Neotuberostemonine Property

Boiling point:: 554.2±50.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
solubility: DMSO: 10 mM
form: A crystalline solid
pka: 8.90±0.70(Predicted)
color: White to off-white
InChIKey: GYOGHROCTSEKDY-UEIGSNQUSA-N
SMILES: N12[C@H]([C@@H]3C[C@H](C)C(=O)O3)C[C@]3([H])[C@@]1([H])[C@@]([H])([C@@H](CC)[C@@]1([H])OC(=O)[C@@H](C)[C@@]31[H])CCCC2

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 30116
Product name: Neotuberostemonine
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 30116
Product name: Neotuberostemonine
Packaging: 10mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 30116
Product name: Neotuberostemonine
Packaging: 5mg
Price: $270
Updated: 2024/03/01

ChemScene

Product number: CS-0023550
Product name: Neotuberostemonine
Packaging: 1mg
Price: $152
Updated: 2021/12/16

AK Scientific

Product number: W1111
Product name: Neotuberostemonine
Packaging: 1mg
Price: $166
Updated: 2021/12/16

More

Less

Neotuberostemonine Chemical Properties,Usage,Production

Description

Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages. Neotuberostemonine demonstrates antitussive properties in guinea pigs.

Chemical Properties

It is soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Stemona japonica.

Uses

Neotuberostemonine is a major bioactive alkaloid of Stemona tuberosa. It can also be used to treat pulmonary fibrosis.

Definition

ChEBI: Neotuberostemonine is an alkaloid. It has a role as a metabolite.

Biological Functions

Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities. It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 μM. Neotuberostemonine (50 μM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells. It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 μmol/kg. Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.

Biological Activity

Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.

Neotuberostemonine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Neotuberostemonine Suppliers

China 106 United States 8 Global 114

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5645
Advantage: 65

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1103
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

More

Less

View Lastest Price from Neotuberostemonine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Neotuberostemonine 143120-46-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-07

Career Henan Chemical Co

Product: Neotuberostemonine 143120-46-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

143120-46-1, NeotuberostemonineRelated Search:

Cevadine veratramine (R,S)-ANATABINE 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one (3S,5S)-5-[(1S,2Z,3aβ,10aα,10bα)-Decahydro-2-(2,5-dihydro-3-methoxy-4-methyl-5-oxofuran-2-ylidene)-1α-methyl-2H-furo[3,2-c]pyrrolo[1,2-a]azepin-8α-yl]-4,5-dihydro-3-methylfuran-2(3H)-one L-Hyoscyamine ProtosteMotinine Xanthiazone VERATRIDINE Xanthiside menisdaurin daurisoline Daurinoline STEMONIDINE Tuberstemonine tuberostemonine

Neotuberostemonine

Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one,8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-,(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-

(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4 -methyl-5-oxotetrahydro-2-furanyl]dodecahydroazepino[3,2,1-hi]fur o[3,2-e]indol-10(2H)-one

(2S,31R,7aR,8R,8aR,11S,11aR,11bS)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one

Neotuberostemonine, 10 mM in DMSO

143120-46-1