Neotuberostemonine

Product Name: Neotuberostemonine
CAS No.: 143120-46-1
Chemical Name: Neotuberostemonine
Synonyms: Neotuberostemonine;(2S,31R,7aR,8R,8aR,11S,11aR,11bS)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one;(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4 -methyl-5-oxotetrahydro-2-furanyl]dodecahydroazepino[3,2,1-hi]fur o[3,2-e]indol-10(2H)-one;Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one,8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-,(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-
CBNumber: CB62519896
Molecular Formula: C22H33NO4
Formula Weight: 375.5
MOL File: 143120-46-1.mol

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Neotuberostemonine Property

Boiling point:: 554.2±50.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
solubility: DMSO: 10 mM
form: A crystalline solid
pka: 8.90±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30116
Product name: Neotuberostemonine
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 30116
Product name: Neotuberostemonine
Packaging: 10mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 30116
Product name: Neotuberostemonine
Packaging: 5mg
Price: $270
Updated: 2024/03/01

ChemScene

Product number: CS-0023550
Product name: Neotuberostemonine
Packaging: 1mg
Price: $152
Updated: 2021/12/16

AK Scientific

Product number: W1111
Product name: Neotuberostemonine
Packaging: 1mg
Price: $166
Updated: 2021/12/16

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Neotuberostemonine Chemical Properties,Usage,Production

Description

Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages. Neotuberostemonine demonstrates antitussive properties in guinea pigs.

Uses

Neotuberostemonine is a major bioactive alkaloid of Stemona tuberosa. It can also be used to treat pulmonary fibrosis.

Definition

ChEBI: Neotuberostemonine is an alkaloid. It has a role as a metabolite.

Biological Functions

Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities. It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 μM. Neotuberostemonine (50 μM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells. It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 μmol/kg. Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.

Biological Activity

Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.

Neotuberostemonine Preparation Products And Raw materials

Raw materials

Preparation Products

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Neotuberostemonine Suppliers

China 82 United States 8 Global 90

Chembest Research Laboratories Limited

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View Lastest Price from Neotuberostemonine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Neotuberostemonine 143120-46-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-07

Career Henan Chemical Co

Product: Neotuberostemonine 143120-46-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

143120-46-1, NeotuberostemonineRelated Search:

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Neotuberostemonine

Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one,8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-,(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-

(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4 -methyl-5-oxotetrahydro-2-furanyl]dodecahydroazepino[3,2,1-hi]fur o[3,2-e]indol-10(2H)-one

(2S,31R,7aR,8R,8aR,11S,11aR,11bS)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one

143120-46-1