ChemicalBook > CAS DataBase List > Neotuberostemonine
Neotuberostemonine
- Product Name
- Neotuberostemonine
- CAS No.
- 143120-46-1
- Chemical Name
- Neotuberostemonine
- Synonyms
- Neotuberostemonine;(2S,31R,7aR,8R,8aR,11S,11aR,11bS)-8-Ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one;(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4 -methyl-5-oxotetrahydro-2-furanyl]dodecahydroazepino[3,2,1-hi]fur o[3,2-e]indol-10(2H)-one;Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one,8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-,(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-
- CBNumber
- CB62519896
- Molecular Formula
- C22H33NO4
- Formula Weight
- 375.5
- MOL File
- 143120-46-1.mol
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Neotuberostemonine Property
- Boiling point:
- 554.2±50.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- solubility
- DMSO: 10 mM
- form
- A crystalline solid
- pka
- 8.90±0.70(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 30116
- Product name
- Neotuberostemonine
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30116
- Product name
- Neotuberostemonine
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30116
- Product name
- Neotuberostemonine
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0023550
- Product name
- Neotuberostemonine
- Packaging
- 1mg
- Price
- $152
- Updated
- 2021/12/16
AK Scientific
- Product number
- W1111
- Product name
- Neotuberostemonine
- Packaging
- 1mg
- Price
- $166
- Updated
- 2021/12/16
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Neotuberostemonine Chemical Properties,Usage,Production
Description
Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages. Neotuberostemonine demonstrates antitussive properties in guinea pigs.
Uses
Neotuberostemonine is a major bioactive alkaloid of Stemona tuberosa. It can also be used to treat pulmonary fibrosis.
Definition
ChEBI: Neotuberostemonine is an alkaloid. It has a role as a metabolite.
Biological Functions
Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities. It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 μM. Neotuberostemonine (50 μM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells. It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 μmol/kg. Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.
Biological Activity
Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.
Neotuberostemonine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Neotuberostemonine manufacturers
Shanghai Standard Technology Co., Ltd.
- Product
- Neotuberostemonine 143120-46-1
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-05-07
Career Henan Chemical Co
- Product
- Neotuberostemonine 143120-46-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30
143120-46-1, NeotuberostemonineRelated Search:
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