(R,S)-ANATABINE

ChemicalBook > CAS DataBase List > (R,S)-ANATABINE

Product Name: (R,S)-ANATABINE
CAS No.: 2743-90-0
Chemical Name: (R,S)-ANATABINE
Synonyms: D,L-ANATABINE;rac-Anatabine;(R,S)-ANATABINE;Nicotine USP RC A;ANATABINE, (+/-)-(RG);Nicotine Impurity A as Racemate;1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE;Nicotine EP Impurity A as Racemate;1,2,3,6-Tetrahydro-2,3'-bipyridine;Anatabine, froM Nicotiana tabacuM L.
CBNumber: CB1382628
Molecular Formula: C10H12N2
Formula Weight: 160.22
MOL File: 2743-90-0.mol

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(R,S)-ANATABINE Property

Boiling point:: 136
Density: 1.045±0.06 g/cm3(Predicted)
storage temp.: Amber Vial, Refrigerator, Under Inert Atmosphere
solubility: ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide
form: solution in ethanol.
pka: 8.84±0.40(Predicted)
color: Light yellow to yellow
Stability:: Hygroscopic, Light Sensitive
CAS DataBase Reference: 2743-90-0

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Safety

Risk Statements: 25-36
Safety Statements: 24/25
RIDADR: 2810
HazardClass: IRRITANT
HS Code: 29399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3060
Product name: Nicotine Related Compound A/EP Impurity A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $576
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1463326
Product name: Nicotine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $1380
Updated: 2024/03/01

Cayman Chemical

Product number: 11001
Product name: (R,S)-Anatabine
Purity: ≥95%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 11001
Product name: (R,S)-Anatabine
Purity: ≥95%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 11001
Product name: (R,S)-Anatabine
Purity: ≥95%
Packaging: 50mg
Price: $241
Updated: 2024/03/01

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(R,S)-ANATABINE Chemical Properties,Usage,Production

Description

(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.

Chemical Properties

Light Yellow Oil

Uses

A nicotine metabolite

Uses

A nicotine (N412420) metabolite.

Uses

(R,S)-Anatabine is a metabolite of Nicotine (N412420).

in vitro

anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1].

in vivo

in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1].

References

[1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391.

(R,S)-ANATABINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R,S)-ANATABINE manufacturers

Nanjing jinheyou Trading Co., Ltd.

Product: (R,S)-ANATABINE 2743-90-0
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-20

2743-90-0, (R,S)-ANATABINERelated Search:

Neotuberostemonine (+/-)-ANABASINE 2,3'-Bipyridine (R,S)-ANATABINE-2,4,5,6-D4 S-(-)-ANATABINE ANATABINE (R,S)-N-NITROSOANATABINE (R,S)-N-NITROSOANATABINE-2,4,5,6-D4 1-(3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)ETHANONE (R,S)-Anatabine-d4 5,5'-DIMETHYL-6,6'-DIPHENYL-1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE 2-CHLORO-1-(3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)ETHANONE (R,S)-ANATABINE BITARTRATE (3-METHYL-6-(5-METHYL-6-PHENYLPYRIDIN-3-YL)-2-PHENYL-5,6-DIHYDROPYRIDIN-1(2H)-YL)(PHENYL)METHANONE (R,S)-ANATABINE

(R,S)-ANATABINE

ANATABINE, (+/-)-(RG)

(+/-)-Anatabine, 3-(1,2,3,6-Tetrahydropyridin-2-yl)pyridine, 2-(Pyridin-3-yl)-1,2,3,6-tetrahydropyridine

Anatabine, froM Nicotiana tabacuM L.

D,L-ANATABINE

1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE

Anatabine, 97%, from Nicotiana tabacum L.

1,2,3,6-Tetrahydro-2,3'-bipyridine 98%

Nicotine USP RC A

1,2,3,6-tetrahydro-2,3'-bipyridine dihydrochloride

Nicotine USP Related Compound A (rac-Nicotine EP Impurity A)

2,3'-Bipyridine, 1,2,3,6-tetrahydro-

(R,S)Anatabine,inhibit,(R,S)-Anatabine,(R,S) Anatabine,Inhibitor

Nicotine Impurity A as Racemate

rac-Anatabine

Nicotine EP Impurity A as Racemate

1,2,3,6-Tetrahydro-2,3'-bipyridine

(R,S)-Anatabine 100μg/mL in Methanol

2743-90-0

27430-90-0

Aromatics

Heterocycles

Metabolites & Impurities

Metabolites

Nicotine Derivatives