3,4,5-TRIMETHOXYCINNAMIC ACID

Product Name: 3,4,5-TRIMETHOXYCINNAMIC ACID
CAS No.: 20329-98-0
Chemical Name: 3,4,5-TRIMETHOXYCINNAMIC ACID
Synonyms: AKOS BBS-00000775;RARECHEM BK HC T328;OTAVA-BB BB7119152925;Cinepazide Impurities4;Cinepazide Impurities1390;(E)-3,4,5-Trimethoxycinnam;(E)-3,4,5-Trimethoxycinnamic;3,4,5-Trimethoxycinnamic acid;(E)-3,4,5-Trimethoxycinnamic Acid;trans-3,4,5-TriMethoxycinnaMic acid
CBNumber: CB4236421
Molecular Formula: C12H14O5
Formula Weight: 238.24
MOL File: 20329-98-0.mol

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3,4,5-TRIMETHOXYCINNAMIC ACID Property

Melting point:: 125-127 °C(lit.)
Boiling point:: 396.4±37.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.48±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+
InChIKey: YTFVRYKNXDADBI-SNAWJCMRSA-N
SMILES: C(O)(=O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1

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Safety

Safety Statements: 24/25
WGK Germany: 2
RTECS: GE0722000
HS Code: 2918.99.4700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T1104
Product name: (E)-3,4,5-Trimethoxycinnamic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $65
Updated: 2025/07/31

Crysdot

Product number: CD12098120
Product name: (E)-3-(3,4,5-Trimethoxyphenyl)acrylicacid
Purity: 97%
Packaging: 100g
Price: $80
Updated: 2021/12/16

Ambeed

Product number: A359956
Product name: (E)-3-(3,4,5-Trimethoxyphenyl)acrylicacid
Purity: 98%
Packaging: 500g
Price: $191
Updated: 2021/12/16

Ambeed

Product number: A359956
Product name: (E)-3-(3,4,5-Trimethoxyphenyl)acrylicacid
Purity: 98%
Packaging: 5g
Price: $7
Updated: 2021/12/16

Ambeed

Product number: A359956
Product name: (E)-3-(3,4,5-Trimethoxyphenyl)acrylicacid
Purity: 98%
Packaging: 10g
Price: $9
Updated: 2021/12/16

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3,4,5-TRIMETHOXYCINNAMIC ACID Chemical Properties,Usage,Production

Uses

(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy[1][2][3].

Definition

ChEBI: 3,4,5-trimethoxycinnamic acid is a methoxycinnamic acid with three methoxy substituents at the 3-, 4- and 5-positions. It has a role as an allergen. It is a conjugate acid of a 3,4,5-trimethoxycinnamate.

in vivo

(E)-3,4,5-Trimethoxycinnamic acid (0-20 mg/kg, IP, once) shows anti-seizure effects^[2].
(E)-3,4,5-Trimethoxycinnamic acid (0-10 mg/kg, Orally, once) enhances hypnotic effects in pentobarbital-treated mice^[3].

Animal Model:	Ault male KunMing-strain mice (18-20 g, maximal electroshock (MES) and pentylenetetrazol (PTZ) models)^[2]
Dosage:	5, 10 and 20 mg/kg; 10 mL/kg
Administration:	IP, once
Result:	Significantly decreased the incidence of MES-induced THE (tonic hindlimb extension) to 50% and 20% of the value of the vehicle controls at 10 and 20 mg/kg. Decreased the incidence of MES-induced THE to only 80% at 5 mg/kg. Significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. The incidence of generalized clonic convulsions (stage 4) disappeared at doses of both 10 and 20 mg/kg.

Animal Model:	ICR male mice (25-28 g, 10-12 in each group)^[3]
Dosage:	2, 5 and 10 mg/kg
Administration:	Orally (p.o.), once, 15 min and 1 h prior to pentobarbital injection
Result:	Significantly decreased locomotor activity at 10 mg/kg. Increased NREM and total sleep, but decreased wakefulness.

IC 50

5-HT_1A Receptor: 7.6 μM (IC₅₀); 5-HT_2C Receptor: 2.5 μM (IC₅₀); 5-HT_2A Receptor: >10 μM (IC₅₀); 5-HT₆ Receptor: >10 μM (IC₅₀); 5-HT₇ Receptor: >10 μM (IC₅₀)

References

[1] Zhao Z, et al. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur J Med Chem. 2019 Jul 1;173:213-227. DOI:10.1016/j.ejmech.2019.04.009
[2] Chen CY, et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. J Pharmacol Sci. 2016 May;131(1):1-5. DOI:10.1016/j.jphs.2015.07.021
[3] Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51. DOI:10.1007/s12272-013-0167-6

3,4,5-TRIMETHOXYCINNAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4,5-TRIMETHOXYCINNAMIC ACID Suppliers

China 115 Finland 1 France 1 Germany 4 India 2 Japan 3 Ukraine 1 United Kingdom 5 United States 13 Global 145

Zaoyang Cixiang Medical Technology Co., Ltd

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View Lastest Price from 3,4,5-TRIMETHOXYCINNAMIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,4,5-TRIMETHOXYCINNAMIC ACID 20329-98-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3,4,5-TRIMETHOXYCINNAMIC ACID 20329-98-0
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

Henan Fengda Chemical Co., Ltd

Product: 3,4,5-TRIMETHOXYCINNAMIC ACID 20329-98-0
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

20329-98-0, 3,4,5-TRIMETHOXYCINNAMIC ACIDRelated Search:

RESCINNAMINE 3,4,5-TRIMETHOXYCINNAMIC ACID ETHYL ESTER 3,4,5-TRIMETHOXYCINNAMIC ACID METHYL 3,4,5-TRIMETHOXYCINNAMATE Styrene 3,4,5-TRIMETHOXYCINNAMIC ACID SODIUM SALT Cinecromen RARECHEM AL BM 0488 (2E)-3-[3,5-DIMETHOXY-4-(PYRIDIN-2-YLMETHOXY)PHENYL]ACRYLIC ACID BENZENEACETIC ACID, 3-HYDROXY-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)- BENZENEACETIC ACID, 3-BROMO-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)- 4-ACETOXY-3,5-DIMETHOXYCINNAMIC ACID RARECHEM AL BM 1076 RARECHEM AL BM 0063 2-BIPHENYL-4-YL-3-(3,4,5-TRIMETHOXY-PHENYL)-ACRYLIC ACID RARECHEM AL BK 1166 RARECHEM AL BM 0701 3,4,5-TRIMETHOXYCINNAMIC ACID ANHYDRIDE

(E)-3-(3,4,5-TRIMETHOXY-PHENYL)-ACRYLIC ACID

AKOS BBS-00000775

3-(3,4,5-TRIMETHOXYPHENYL)ACRYLIC ACID

(E)-3-(3,4,5-Trimethoxyphenyl)propenoic acid

3,4,5-Trimethoxycinnamic acid

OTAVA-BB BB7119152925

RARECHEM BK HC T328

<i>trans</i>-3,4,5-TriMethoxycinnaMic acid

trans-3,4,5-TriMethoxycinnaMic acid

3,4,5-Trimethoxy-trans-cinnamic acid

(E)-3,4,5-Trimethoxycinnamic Acid

2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, (2E)-

(E)-3,4,5-Trimethoxycinnamic

3,4,5-TRIMETHOXYCINNAMIC ACID USP/EP/BP

Cinepazide Impurities1390

Cinepazide Impurities4

(E)-3,4,5-Trimethoxycinnam

(E)-3,4,5-Trimethoxycinnamic acid, 10 mM in DMSO

20329-98-0

Organic Building Blocks

Carboxylic Acids

Carbonyl Compounds

C11 to C12

Building Blocks