ChemicalBook > CAS DataBase List > 2-Bromo-6-chlorobenzoic acid

2-Bromo-6-chlorobenzoic acid

Product Name
2-Bromo-6-chlorobenzoic acid
CAS No.
93224-85-2
Chemical Name
2-Bromo-6-chlorobenzoic acid
Synonyms
AKOS MSC-0781;BUTTPARK 51\01-28;2-Bromo-6-chlorobenzoicaci;6-bromo-2-chloroBenzoic acid;2-BROMO-6-CHLOROBENZOIC ACID;3-bromo-2-chloro-benzoic acid;Benzoic acid, 2-broMo-6-chloro-;2-Bromo-6-chlorobenzoic acid, CAS 93224-85-2;2-Bromo-6-chlorobenzoic acid ISO 9001：2015 REACH
CBNumber
CB4236698
Molecular Formula
C7H4BrClO2
Formula Weight
235.46
MOL File
93224-85-2.mol
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2-Bromo-6-chlorobenzoic acid Property

Melting point:
148-152 °C
Boiling point:
315.9±27.0 °C(Predicted)
Density 
1.809±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
powder to crystal
pka
1.62±0.10(Predicted)
color 
White to Orange to Green
InChIKey
URGXUQODOUMRFP-UHFFFAOYSA-N
CAS DataBase Reference
93224-85-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
2811
WGK Germany 
2
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4820
Product name
2-Bromo-6-chlorobenzoic Acid
Purity
min. 98.0 %
Packaging
1G
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
B4820
Product name
2-Bromo-6-chlorobenzoic Acid
Purity
min. 98.0 %
Packaging
5G
Price
$88
Updated
2025/07/31
TRC
Product number
B682535
Product name
2-Bromo-6-chlorobenzoic acid
Packaging
25g
Price
$450
Updated
2021/12/16
AK Scientific
Product number
J51409
Product name
2-Bromo-6-chlorobenzoic acid
Packaging
5g
Price
$12
Updated
2021/12/16
Matrix Scientific
Product number
026302
Product name
2-Bromo-6-chlorobenzoic acid
Purity
98%
Packaging
5g
Price
$12
Updated
2021/12/16
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2-Bromo-6-chlorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

2-Bromo-6-chlorobenzoic acid is used in the syntheis of Diclofenac Monobromo Sodium Salt Impurity (D436490).

Synthesis

108-37-2

124-38-9

93224-85-2

Step 1. Synthesis of 2-bromo-6-chlorobenzoic acid: Diisopropylamine (3.5 mL, 25 mmol) was slowly added to a tetrahydrofuran (THF, 70 mL) solution of n-butyllithium (n-BuLi, 10 mL, 25 mmol, 2.5 M hexane solution) cooled at -78 °C under anhydrous conditions. After stirring the reaction mixture for 15 minutes, 1-chloro-3-bromobenzene (4.32 g, 25 mmol) was added dropwise and stirring was continued at -78 °C for 2 hours. Subsequently, dry ice (solid CO2) was added to the reaction system and after 15 min of reaction, aqueous 2N hydrochloric acid (100 mL) was slowly added to quench the reaction. The reaction mixture was extracted with ethyl acetate (EtOAc) and the organic phases were combined. The product was purified by recrystallization from hexane and finally isolated to give 5 g of 2-bromo-6-chlorobenzoic acid in 85% yield.

References

[1] Organic Letters, 2009, vol. 11, # 5, p. 1051 - 1054
[2] Tetrahedron Letters, 1997, vol. 38, # 9, p. 1559 - 1562
[3] Patent: WO2008/124582, 2008, A1. Location in patent: Page/Page column 117
[4] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 108
[5] Organic Process Research and Development, 2005, vol. 9, # 6, p. 764 - 767

2-Bromo-6-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-6-chlorobenzoic acid manufacturers

Career Henan Chemical Co
Product
2-Bromo-6-chlorobenzoic acid 93224-85-2
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

93224-85-2, 2-Bromo-6-chlorobenzoic acidRelated Search:

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  • 6-bromo-2-chloroBenzoic acid
  • Benzoic acid, 2-broMo-6-chloro-
  • 3-bromo-2-chloro-benzoic acid
  • BUTTPARK 51\01-28
  • 2-BROMO-6-CHLOROBENZOIC ACID
  • AKOS MSC-0781
  • 2-Bromo-6-chlorobenzoic acid ISO 9001：2015 REACH
  • 2-Bromo-6-chlorobenzoicaci
  • 2-Bromo-6-chlorobenzoic acid, CAS 93224-85-2
  • 93224-85-2
  • C42H24Br6Cl6O12
  • C7H4BrClO2
  • Acids and Esters
  • Acids & Esters
  • Bromine Compounds
  • Chlorine Compounds
  • blocks
  • Bromides
  • Carboxes
  • Benzoic acid
  • API intermediates