DIACYLGLYCEROL KINASE INHIBITOR II
- Product Name
- DIACYLGLYCEROL KINASE INHIBITOR II
- CAS No.
- 120166-69-0
- Chemical Name
- DIACYLGLYCEROL KINASE INHIBITOR II
- Synonyms
- R59949;R-59949(R-59-949);DAG Kinase Inhibitor;DAG Kinase Inhibitor II;DIACYLGLYCEROL KINASE INHIBITOR II;Diacylglycerol Kinase Inhibitor II solid;DIACYLGLYCEROL KINASE INHIBITOR I (R59 949);DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949);Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem;3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
- CBNumber
- CB4239260
- Molecular Formula
- C28H25F2N3OS
- Formula Weight
- 489.58
- MOL File
- 120166-69-0.mol
DIACYLGLYCEROL KINASE INHIBITOR II Property
- Melting point:
- 228-230 °C
- Boiling point:
- 637.1±65.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- 0.1 M HCl: slightly soluble
- form
- solid
- pka
- 11.24±0.20(Predicted)
- color
- pale yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D5794
- Product name
- Diacylglycerol Kinase Inhibitor II
- Purity
- solid
- Packaging
- 1mg
- Price
- $36.18
- Updated
- 2024/03/01
- Product number
- 266788
- Product name
- Diacylglycerol Kinase Inhibitor II
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 21221
- Product name
- R-59-949
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21221
- Product name
- R-59-949
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- D5794
- Product name
- Diacylglycerol Kinase Inhibitor II
- Purity
- solid
- Packaging
- 5mg
- Price
- $173
- Updated
- 2024/03/01
DIACYLGLYCEROL KINASE INHIBITOR II Chemical Properties,Usage,Production
Description
R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner. In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Uses
Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.
Definition
ChEBI: 3-[2-[4-[bis(4-fluorophenyl)methylidene]-1-piperidinyl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one is a diarylmethane.
Biochem/physiol Actions
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.