1-Fluoro-4-(1-methylethenyl)benzene
- Product Name
- 1-Fluoro-4-(1-methylethenyl)benzene
- CAS No.
- 350-40-3
- Chemical Name
- 1-Fluoro-4-(1-methylethenyl)benzene
- Synonyms
- 4-Fluoro-α4-fluoro-methylstyrene;Fluoroalphamethylstyrene;4-FLUORO-A-METHYLSTYRENE;4-fluoro-à-methylstyrene;-oxo-benzeneacetaldehyde;4-Fluoro-α-methylstyrene;p-Fluoro-α-methylstyrene;2-(4-FLUOROPHENYL)PROPENE;P-Fluoro-alfa-methylstyrene
- CBNumber
- CB2198778
- Molecular Formula
- C9H9F
- Formula Weight
- 136.17
- MOL File
- 350-40-3.mol
1-Fluoro-4-(1-methylethenyl)benzene Property
- Boiling point:
- 183°C
- Density
- 1.01 g/mL at 20 °C(lit.)
- refractive index
- 1.5085-1.5125
- Flash point:
- 53 °C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- soluble in Methanol
- form
- clear liquid
- color
- colorless to yellow/brown
- BRN
- 2039696
- CAS DataBase Reference
- 350-40-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-FC6H4C(CH3)=CH2(350-40-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CDS001211
- Product name
- 4-Fluoro-α-methylstyrene
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 500 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- F0250
- Product name
- 4-Fluoro-alpha-methylstyrene (stabilized with TBC)
- Purity
- >98.0%(GC)
- Packaging
- 5mL
- Price
- $86
- Updated
- 2025/07/31
- Product number
- F0250
- Product name
- 4-Fluoro-alpha-methylstyrene (stabilized with TBC)
- Purity
- >98.0%(GC)
- Packaging
- 25mL
- Price
- $249
- Updated
- 2025/07/31
- Product number
- F594000
- Product name
- 4-Fluoro-α-methylstyrene
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- F594000
- Product name
- 4-Fluoro-α-methylstyrene
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
1-Fluoro-4-(1-methylethenyl)benzene Chemical Properties,Usage,Production
Chemical Properties
clear colorless to yellowish liquid
Uses
4-Fluoro-a-methylstyrene is used in the synthesis of Paroxetine (P205750), which is a selective serotonin reuptake inhibitor. Used as an antidepressant.
Synthesis
1779-49-3
403-42-9
350-40-3
GENERAL METHOD: Potassium tert-butoxide (t-BuOK, 2.47 g, 22.00 mmol) was added to an anhydrous tetrahydrofuran (THF, 70 mL) solution of methyltriphenylphosphonium bromide (7.12 g, 20.00 mmol) in four batches at 0 °C. The reaction mixture was stirred at 0 °C for 2 h, followed by slow dropwise addition of anhydrous THF (20 mL) solution of 4-fluoroacetophenone (20 mmol) over 30 min. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl, 50 mL) solution. The reaction solution was extracted three times with petroleum ether (3 x 50 mL). All organic phases were combined, washed with saturated saline (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Finally, the residue was purified by fast column chromatography using petroleum ether (Pet) as eluent to afford the target product 1-fluoro-4-(prop-1-en-2-yl)benzene.
References
[1] Tetrahedron, 2008, vol. 64, # 37, p. 8610 - 8617
[2] Organic Letters, 2018, vol. 20, # 18, p. 5747 - 5751
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 32, p. 8450 - 8453
[4] Angew. Chem., 2013, vol. 125, # 32, p. 8608 - 8611,4
[5] Tetrahedron, 2017, vol. 73, # 49, p. 6901 - 6905
1-Fluoro-4-(1-methylethenyl)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Fluoro-4-(1-methylethenyl)benzene manufacturers
- Product
- 1-Fluoro-4-(1-methylethenyl)benzene 350-40-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 1-Fluoro-4-(1-methylethenyl)benzene 350-40-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-05-30