Methyl 3-cyclopropyl-3-oxopropionate
- Product Name
- Methyl 3-cyclopropyl-3-oxopropionate
- CAS No.
- 32249-35-7
- Chemical Name
- Methyl 3-cyclopropyl-3-oxopropionate
- Synonyms
- METHYL 3-CYCLOPROPYL-3-OXOPROPANOATE;MCOP;BUTTPARK 30\10-64;Pitavastatin Impurity 79;-3-oxo-propionic acid methyL;Methyl β-oxocyclopropanepropanoate;METHYL 3-CYCLOPROPYL-3-OXOPROPIONATE;Methyl 2-(Cyclopropylcarbonyl)acetate;Methyl3-Cyclopropyl-3-oxopropionate>Methyl 3-cyclopropyl-3-oxopropanoate 95%
- CBNumber
- CB4244420
- Molecular Formula
- C7H10O3
- Formula Weight
- 142.15
- MOL File
- 32249-35-7.mol
Methyl 3-cyclopropyl-3-oxopropionate Property
- Boiling point:
- 193°C
- Density
- 1.174
- refractive index
- 1.4500 to 1.4540
- Flash point:
- 74°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform
- form
- Oil
- pka
- 10.59±0.20(Predicted)
- color
- Clear Colorless
- InChI
- InChI=1S/C7H10O3/c1-10-7(9)4-6(8)5-2-3-5/h5H,2-4H2,1H3
- InChIKey
- RIJWDPRXCXJDPK-UHFFFAOYSA-N
- SMILES
- C1(CC1)C(=O)CC(=O)OC
- CAS DataBase Reference
- 32249-35-7(CAS DataBase Reference)
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2277
- Product name
- Methyl 3-Cyclopropyl-3-oxopropionate
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- M2277
- Product name
- Methyl 3-Cyclopropyl-3-oxopropionate
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- C988775
- Product name
- 3-Cyclopropyl-3-oxopropanoicAcidMethylEster
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FC20729
- Product name
- 3-Cyclopropyl-3-oxopropanoic acid methyl ester
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- API0004940
- Product name
- 3-CYCLOPROPYL-3-OXO-PROPIONIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $124.95
- Updated
- 2021/12/16
Methyl 3-cyclopropyl-3-oxopropionate Chemical Properties,Usage,Production
Chemical Properties
Methyl 3-cyclopropyl-3-oxopropionate is Clear Colorless Oil
Uses
Methyl 3-cyclopropyl-3-oxopropionate is a reagent used in the synthesis of Pitavastatin.
Synthesis
67-56-1
2033-24-1
4023-34-1
32249-35-7
Cyclo(sub)isopropyl malonate (50 g; 347 mmol) was dissolved in chloroform (550 ml) followed by addition of pyridine (56 g; 700 mmol). A solution of cyclopropanecarbonyl chloride (40 g; 383 mmol) in chloroform (50 ml) was added slowly and dropwise under cooling in an ice bath, keeping the reaction temperature below 10 °C. After the dropwise addition, the reaction mixture was continued to be stirred in an ice bath for 1 h. Subsequently, the ice bath was withdrawn and the reaction was stirred for another 1 h at room temperature. After completion of the reaction, the reaction was again cooled in an ice bath and the reaction was quenched by slow addition of 1N aqueous hydrochloric acid solution (500 ml). The reaction product was extracted with chloroform, the organic phase was washed sequentially with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. Methanol (500 ml) was added to the concentrated residue and heated to reflux for 3 hours. After the reaction solution was cooled to room temperature, methanol was removed by distillation under reduced pressure, and the residue was purified by distillation under reduced pressure to obtain 3-cyclopropyl-3-oxopropanoic acid methyl ester 40g, yield 80%. Physical properties: boiling point 80°C (10mmHg).
References
[1] Patent: EP1852428, 2007, A1. Location in patent: Page/Page column 31
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 24, p. 6836 - 6840
Methyl 3-cyclopropyl-3-oxopropionate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-cyclopropyl-3-oxopropionate Suppliers
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View Lastest Price from Methyl 3-cyclopropyl-3-oxopropionate manufacturers
- Product
- Methyl 3-cyclopropyl-3-oxopropionate 32249-35-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2024-01-03
- Product
- Methyl 3-cyclopropyl-3-oxopropionate 32249-35-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-03