4-(BROMOMETHYL)-2-CHLOROPYRIDINE
- Product Name
- 4-(BROMOMETHYL)-2-CHLOROPYRIDINE
- CAS No.
- 83004-15-3
- Chemical Name
- 4-(BROMOMETHYL)-2-CHLOROPYRIDINE
- Synonyms
- 2-chloro-4-(bromomethyl)pyridine;4-(BROMOMETHYL)-2-CHLOROPYRIDINE;Pyridine, 4-(bromomethyl)-2-chloro-;4-(BROMOMETHYL)-2-CHLOROPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB42448587
- Molecular Formula
- C6H5BrClN
- Formula Weight
- 206.47
- MOL File
- 83004-15-3.mol
4-(BROMOMETHYL)-2-CHLOROPYRIDINE Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B870095
- Product name
- 4-(bromomethyl)-2-chloropyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0353867
- Product name
- 4-BROMOMETHYL-2-CHLORO-PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.01
- Updated
- 2021/12/16
- Product number
- Y1576
- Product name
- 4-(Bromomethyl)-2-chloropyridine
- Packaging
- 5g
- Price
- $1237
- Updated
- 2021/12/16
- Product number
- CM123906
- Product name
- 4-(bromomethyl)-2-chloropyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $832
- Updated
- 2021/12/16
- Product number
- CD11050209
- Product name
- 4-(Bromomethyl)-2-chloropyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $890
- Updated
- 2021/12/16
4-(BROMOMETHYL)-2-CHLOROPYRIDINE Chemical Properties,Usage,Production
Synthesis
100704-10-7
83004-15-3
Step 4b: (2-chloropyridin-4-yl)methanol (1.1 g, 7.3 mmol) was dissolved in 20 mL of dichloromethane (DCM) and cooled to 0°C after displacing the air within the reaction system with argon. Phosphorus tribromide (PBr3, 0.76 mL, 8.1 mmol) was added slowly dropwise via syringe and the solution was observed to become turbid. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to 0 °C again and the reaction was quenched with 5 mL of water. The pH was adjusted by adding 2 M potassium carbonate (K2CO3) solution to the reaction mixture. the aqueous and organic layers were separated, and the aqueous layer was extracted three times with ethyl acetate (EtOAc). The aqueous layer was extracted with ethyl acetate (EtOAc) three times. All organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. The concentrate was purified by silica gel column chromatography (the silica gel column was pre-washed with an eluent containing 1% triethylamine (NEt3)) using a gradient elution from hexane to ethyl acetate (EtOAc) to afford the target product, 4-bromomethyl-2-chloropyridine, as pale pink crystals (700 mg, calculated as 50% yield based on the recovered starting material). The product was confirmed by NMR hydrogen spectroscopy (300 MHz, CDCl3): δ 8.37 (d, J=5.1 Hz, 1H), 7.35 (s, 1H), 7.27-7.20 (m, 1H), 4.35 (s, 2H).
References
[1] Patent: WO2011/147038, 2011, A1. Location in patent: Page/Page column 43-44
[2] Patent: WO2016/97345, 2016, A1. Location in patent: Page/Page column 16; 17
[3] Patent: EP1602647, 2005, A1. Location in patent: Page/Page column 54
[4] Patent: US2004/248884, 2004, A1. Location in patent: Page 120
[5] Patent: WO2011/25851, 2011, A1. Location in patent: Page/Page column 58
4-(BROMOMETHYL)-2-CHLOROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(BROMOMETHYL)-2-CHLOROPYRIDINE manufacturers
- Product
- 4-(Bromomethyl)-2-Chloropyridine 83004-15-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10
- Product
- 4-(BROMOMETHYL)-2-CHLOROPYRIDINE 83004-15-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-07