ENIPORIDE
- Product Name
- ENIPORIDE
- CAS No.
- 176644-21-6
- Chemical Name
- ENIPORIDE
- Synonyms
- CS-1337;CS-1941;ENIPORID;EMD 96785;ENIPORIDE;EMD 96785,ENIPORIDE;EMD-96785;EMD 96785;Eniporide(EMD96785);N-Carbamimidoyl-2-methyl-5-(methylsulfonyl);N-CarbaMiMidoyl-2-Methyl-5-(Methylsulfonyl)-4-(1H-pyrrol-1-yl)benzaMide
- CBNumber
- CB42448961
- Molecular Formula
- C14H16N4O3S
- Formula Weight
- 320.37
- MOL File
- 176644-21-6.mol
ENIPORIDE Property
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- ≤5mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 10.63±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20984
- Product name
- Eniporide
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 20984
- Product name
- Eniporide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 20984
- Product name
- Eniporide
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $311
- Updated
- 2024/03/01
- Product number
- 20984
- Product name
- Eniporide
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $638
- Updated
- 2024/03/01
- Product number
- C3709
- Product name
- Eniporide
- Packaging
- 25mg
- Price
- $705
- Updated
- 2021/12/16
ENIPORIDE Chemical Properties,Usage,Production
Description
Eniporide is a selective inhibitor of human Na+/H+ exchanger isoform 1 (NHE-1) (IC50 = 4.5 nM). Inhibition with eniporide prevents calcium overload-induced myocardial ischemia-reperfusion injury in vitro and in vivo.
in vitro
eniporide was identified as a selective inhibitor of na+-h+ exchange and a compound of the benzoylguanidine group. in addition, eniporide and its metabolite were found to inhibit the na+-h+ exchange in acidified rabbit erythrocytes with an ic50 value of 4.7 ± 0.6 and 15 ± 3 nm, respectively [1].
in vivo
animal study showed that the pretreatment of the mice with the eniporide led to a substantial decrease of annexin-v–positive cardiomyocytes in the i/r 30/90 group from 20.2% to 2.2%. moreover, the pretreatment of i/r 30/90 mice with eniporide resulted in the complete absence of igg-positive cells, suggesting that the cardiomyocytes with extensive cell membrane leakage were a result of an active cell death program [2].
IC 50
4.7 nm
References
[1] bhattaram va, nagaraja nv, peters t, machnig t, kroesser s, kovar a, derendorf h. population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction. j clin pharmacol. 2005 jun;45(6):631-9.
[2] dumont ea et al. cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-v in a mouse model. circulation. 2000 sep 26;102(13):1564-8.
ENIPORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ENIPORIDE Suppliers
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View Lastest Price from ENIPORIDE manufacturers
- Product
- ENIPORIDE 176644-21-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12