ChemicalBook > CAS DataBase List > ENIPORIDE

ENIPORIDE

Product Name: ENIPORIDE
CAS No.: 176644-21-6
Chemical Name: ENIPORIDE
Synonyms: CS-1337;CS-1941;ENIPORID;EMD 96785;ENIPORIDE;EMD 96785,ENIPORIDE;EMD-96785;EMD 96785;Eniporide(EMD96785);Eniporide, 10 mM in DMSO;N-Carbamimidoyl-2-methyl-5-(methylsulfonyl)
CBNumber: CB42448961
Molecular Formula: C14H16N4O3S
Formula Weight: 320.37
MOL File: 176644-21-6.mol

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ENIPORIDE Property

Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: ≤5mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 10.63±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20984
Product name: Eniporide
Purity: ≥95%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 20984
Product name: Eniporide
Purity: ≥95%
Packaging: 5mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 20984
Product name: Eniporide
Purity: ≥95%
Packaging: 10mg
Price: $311
Updated: 2024/03/01

Cayman Chemical

Product number: 20984
Product name: Eniporide
Purity: ≥95%
Packaging: 25mg
Price: $638
Updated: 2024/03/01

ApexBio Technology

Product number: C3709
Product name: Eniporide
Packaging: 25mg
Price: $705
Updated: 2021/12/16

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ENIPORIDE Chemical Properties,Usage,Production

Description

Eniporide is a selective inhibitor of human Na⁺/H⁺ exchanger isoform 1 (NHE-1) (IC₅₀ = 4.5 nM). Inhibition with eniporide prevents calcium overload-induced myocardial ischemia-reperfusion injury in vitro and in vivo.

Uses

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2].

in vitro

eniporide was identified as a selective inhibitor of na+-h+ exchange and a compound of the benzoylguanidine group. in addition, eniporide and its metabolite were found to inhibit the na+-h+ exchange in acidified rabbit erythrocytes with an ic50 value of 4.7 ± 0.6 and 15 ± 3 nm, respectively [1].

in vivo

animal study showed that the pretreatment of the mice with the eniporide led to a substantial decrease of annexin-v–positive cardiomyocytes in the i/r 30/90 group from 20.2% to 2.2%. moreover, the pretreatment of i/r 30/90 mice with eniporide resulted in the complete absence of igg-positive cells, suggesting that the cardiomyocytes with extensive cell membrane leakage were a result of an active cell death program [2].

IC 50

4.7 nm

References

[1] bhattaram va, nagaraja nv, peters t, machnig t, kroesser s, kovar a, derendorf h. population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction. j clin pharmacol. 2005 jun;45(6):631-9.
[2] dumont ea et al. cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-v in a mouse model. circulation. 2000 sep 26;102(13):1564-8.

ENIPORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ENIPORIDE manufacturers

Career Henan Chemical Co

Product: ENIPORIDE 176644-21-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

176644-21-6, ENIPORIDERelated Search:

ENIPORIDE

EMD 96785

N-(Aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide

N-(Diaminomethylene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide

N-(diaMinoMethylidene)-2-Methyl-5-Methylsulfonyl-4-pyrrol-1-ylbenzaMide

N-CarbaMiMidoyl-2-Methyl-5-(Methylsulfonyl)-4-(1H-pyrrol-1-yl)benzaMide

ENIPORID

EMD 96785,ENIPORIDE

N-Carbamimidoyl-2-methyl-5-(methylsulfonyl)

CS-1941

CS-1337

EMD-96785;EMD 96785

Eniporide(EMD96785)

Benzamide, N-(aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)-

Eniporide, 10 mM in DMSO

176644-21-6

76644-21-6

Inhibitors