2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID
- Product Name
- 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID
- CAS No.
- 147030-48-6
- Chemical Name
- 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID
- Synonyms
- KB130015;KB 130015; KB-130015;2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran;2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID;2-[2,6-Diiodo-4-(2-Methyl-1-benzofuran-3-ylMethyl)phenoxy]acetic acid;Acetic acid, 2-[2,6-diiodo-4-[(2-methyl-3-benzofuranyl)methyl]phenoxy]-
- CBNumber
- CB42457068
- Molecular Formula
- C18H14I2O4
- Formula Weight
- 548.11
- MOL File
- 147030-48-6.mol
2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID Property
- storage temp.
- -20°C
- solubility
- DMSO: 10 mg/ml,Ethanol: 10 mg/ml
- form
- A crystalline solid
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- HCH0346199
- Product name
- 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.3
- Updated
- 2021/12/16
2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID Chemical Properties,Usage,Production
Uses
KB130015 (KB015) is an orally active and potent ThRα and ThRβ (Thyroid Hormone Receptor) inhibitor, with IC50 values of 4.5 and 5.1 μM, respectively. KB130015 has antiarrhythmic properties. KB130015 markedly slows the kinetics of inactivation of Na+ channels. KB130015 opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle[1][2][3].
References
[1] Carlsson B, et al. Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. J Med Chem. 2002 Jan 31;45(3):623-30. DOI:10.1021/jm001126+
[2] Mubagwa K, Macianskiene R, Viappiani S, Gendviliene V, Carlsson B, Brandts B. KB130015, a new amiodarone derivative with multiple effects on cardiac ion channels. Cardiovasc Drug Rev. 2003 Fall;21(3):216-35. DOI:10.1111/j.1527-3466.2003.tb00117.x
[3] Gessner G, et al. The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle. Eur J Pharmacol. 2007 Jan 26;555(2-3):185-93. DOI:10.1016/j.ejphar.2006.10.053
2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID Preparation Products And Raw materials
Raw materials
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