2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID

Product Name: 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID
CAS No.: 147030-48-6
Chemical Name: 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID
Synonyms: KB130015;KB 130015; KB-130015;2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran;2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID;2-[2,6-Diiodo-4-(2-Methyl-1-benzofuran-3-ylMethyl)phenoxy]acetic acid;Acetic acid, 2-[2,6-diiodo-4-[(2-methyl-3-benzofuranyl)methyl]phenoxy]-
CBNumber: CB42457068
Molecular Formula: C18H14I2O4
Formula Weight: 548.11
MOL File: 147030-48-6.mol

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2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID Property

storage temp.: -20°C
solubility: DMSO: 10 mg/ml,Ethanol: 10 mg/ml
form: A crystalline solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0346199
Product name: 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $498.3
Updated: 2021/12/16

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2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID Chemical Properties,Usage,Production

Uses

KB130015 (KB015) is an orally active and potent ThRα and ThRβ (Thyroid Hormone Receptor) inhibitor, with IC50 values of 4.5 and 5.1 μM, respectively. KB130015 has antiarrhythmic properties. KB130015 markedly slows the kinetics of inactivation of Na+ channels. KB130015 opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle[1][2][3].

References

[1] Carlsson B, et al. Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. J Med Chem. 2002 Jan 31;45(3):623-30. DOI:10.1021/jm001126+
[2] Mubagwa K, Macianskiene R, Viappiani S, Gendviliene V, Carlsson B, Brandts B. KB130015, a new amiodarone derivative with multiple effects on cardiac ion channels. Cardiovasc Drug Rev. 2003 Fall;21(3):216-35. DOI:10.1111/j.1527-3466.2003.tb00117.x
[3] Gessner G, et al. The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle. Eur J Pharmacol. 2007 Jan 26;555(2-3):185-93. DOI:10.1016/j.ejphar.2006.10.053

2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID Preparation Products And Raw materials

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147030-48-6, 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACIDRelated Search:

2-BUTYL-3-(3,5-DIIODO-4-(OXYACETIC ACID ETHYL ESTER)-BENZOYL)-BENZOFURAN 3-[(3,5-DIIODO-4-HYDROXYPHENYL)METHYL]-2-METHYLBENZOFURAN 2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID

2,6-DIIODO-4-[(2-METHYLBENZOFURAN-3-YL)METHYL]-PHENOXYACETIC ACID

2-[2,6-Diiodo-4-(2-Methyl-1-benzofuran-3-ylMethyl)phenoxy]acetic acid

KB130015

KB 130015; KB-130015

Acetic acid, 2-[2,6-diiodo-4-[(2-methyl-3-benzofuranyl)methyl]phenoxy]-

2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran

147030-48-6

C18H14I2O4