N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Product Name: N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.: 879275-33-9
Chemical Name: N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
Synonyms: (R)-3-N-Boc-AMinoMethylpiperidine;-tert-Butyl (piperidin-3-ylmethyl);(R)-N-Boc-1-(3-piperidyl)methanamine;R-3-N-BOC-AMINOMETHYL PIPERIDINE-HCL 97+%;tert-Butyl (R)-piperidin-3-ylmethylcarbamate;tert-butyl N-[(3R)-piperidin-3-ylmethyl]carbamat;tert-butyl N-[[(3R)-3-piperidyl]methyl]carbamate;tert-butyl N-[(3R)-piperidin-3-ylMethyl]carbaMate;tert-butyl {[(3R)-piperidin-3-yl]methyl}carbamate;1,1-Dimethylethyl N-[(3R)-3-piperidinylmethyl]carbamate
CBNumber: CB42463760
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 879275-33-9.mol

More

Less

N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Property

Boiling point:: 321.8±15.0 °C(Predicted)
Density: 0.981
storage temp.: 2-8°C(protect from light)
pka: 12.71±0.46(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

TRC

Product number: T206013
Product name: (R)-tert-ButylPiperidin-3-ylmethylcarbamateHydrochloride
Packaging: 500mg
Price: $90
Updated: 2021/12/16

TRC

Product number: T206013
Product name: (R)-tert-ButylPiperidin-3-ylmethylcarbamateHydrochloride
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Activate Scientific

Product number: AS55017-3R
Product name: (R)-3-(Boc-aminomethyl)piperidine
Purity: 97+% ee
Packaging: 1g
Price: $66
Updated: 2021/12/16

AK Scientific

Product number: 1211AL
Product name: (R)-3-(Boc-aminomethyl)piperidine
Packaging: 5g
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 1211AL
Product name: (R)-3-(Boc-aminomethyl)piperidine
Packaging: 1g
Price: $91
Updated: 2021/12/16

More

Less

N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Synthesis

142643-29-6

879275-33-9

The general procedure for the synthesis of tert-butyl (R)-[[piperidin-3-yl]methyl]carbamate from 3-Boc-aminomethylpiperidine is as follows:Example 3 Synthesis of (3R)-N-(tert-butoxycarbonyl)-3-aminomethylpiperidine (Compound 4); 4N-(tert-butoxycarbonyl)-3-aminomethylpiperidine (10 g, 1 eq, 47 mmol) was mixed with (+)-0,. 0'-di-p-tolyl-D-tartaric acid (15.52 g, 1 eq, 47 mmol) were mixed in dry methanol (100 ml) and slowly heated to reflux to form a solution. The solution was cooled to room temperature and stirred at that temperature for 5-6 h. A white suspension was obtained, filtered and washed with a minimal amount of anhydrous methanol. The crude salt was recrystallized once by methanol and the resulting salt was suspended in distilled water (25 ml) and cooled to 0°C. Subsequently 10% sodium carbonate solution (100 ml) was added in batches until the suspension became strongly basic. The reaction mixture was continued to be stirred for 10 min and extracted with ethyl acetate (5 x 50 ml). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give compound 4. Yield: 3.2 g in 62% yield. [α]D °C: -8.97 (c=1.0; methanol). Melting point: 64-66°C. IR (Neat): 3362, 2970, 1703, 1520, 1454, 1365, 1172 cm-1. 1H NMR (CDCl3, 300MHz) δ 1.00-1.22 (m, 2H, H-4); 1.40 (s, 9H, -O-C(CH3)3); 1.57-1.72 (m, 3H, H-3, H-5); 2.21-2.32 (m, 1H, CHaNHBoc); 2.44-2.57 (m, 1H, CHbNHBoc); 2.92-3.05 (m, 4H, H-2, H-4); 4.72 (brs, 1H, NH).13C NMR (CDCl3, 300MHz) 26.56 , 29.03, 29.58, 38.44, 44.99, 47.46, 51.16, 79.73, 156.72. FAB MS (m/z): 215 [M+1]+.

References

[1] Patent: WO2012/104866, 2012, A1. Location in patent: Page/Page column 16-17
[2] Patent: WO2006/28904, 2006, A1. Location in patent: Page/Page column 280

N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Suppliers

China 64 India 2 United Kingdom 1 United States 7 Global 74

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 1009
Advantage: 64

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1733
Advantage: 55

Shanghai Arbor Chemical Co., Ltd.

Tel: 021-60451683 15021268886
Fax: +86-21-60451682
Email: sales@arborchemical.com
Country: China
ProdList: 896
Advantage: 55

YangZhou Ruihong Biotech Co., Ltd.

Tel: 0514-015380367604 15380367604
Fax: 0514-83828236
Email: sales@ruibobiotech.com
Country: China
ProdList: 511
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6874
Advantage: 55

More

Less

View Lastest Price from N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER manufacturers

Career Henan Chemical Co

Product: -[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER 879275-33-9
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

879275-33-9, N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTERRelated Search:

N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER tert-butyl 2,6-diazaspiro[3.5]nonane-2-carboxylate (S)-BENZYL-3-((TERT-BUTOXYCARBONYLAMINO)METHYL)PIPERIDINE-1-CARBOXYLATE 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONANE 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

R-3-N-BOC-AMINOMETHYL PIPERIDINE-HCL 97+%

-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

tert-butyl N-[(3R)-piperidin-3-ylMethyl]carbaMate

tert-butyl N-[(3R)-piperidin-3-ylmethyl]carbamat

-tert-Butyl (piperidin-3-ylmethyl)

tert-Butyl (R)-piperidin-3-ylmethylcarbamate

(R)-3-N-Boc-AMinoMethylpiperidine

(R)-N-Boc-1-(3-piperidyl)methanamine

Carbamic acid, N-[(3R)-3-piperidinylmethyl]-, 1,1-dimethylethyl ester

1,1-Dimethylethyl N-[(3R)-3-piperidinylmethyl]carbamate

tert-butyl N-[[(3R)-3-piperidyl]methyl]carbamate

tert-butyl {[(3R)-piperidin-3-yl]methyl}carbamate

879275-33-9