3-AMINOPROPIONITRILE FUMARATE Property

Melting point:

177 °C (dec.)(lit.)

storage temp. 

-20°C

form 

Crystalline Powder

color 

White

Water Solubility 

almost transparency

BRN 

3573532

CAS DataBase Reference

2079-89-2(CAS DataBase Reference)

EPA Substance Registry System

Propanenitrile, 3-amino-, (2E)-2-butenedioate (2:1) (2079-89-2)

Safety

Hazard Codes 

T

Risk Statements 

61

Safety Statements 

53-45

WGK Germany 

3

RTECS 

UG0700000

TSCA 

Yes

HS Code 

29269095

Toxicity

LDLo orl-rat: 800 mg/kg TJADAB 5,33,72

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

3-AMINOPROPIONITRILE FUMARATE Chemical Properties,Usage,Production

Chemical Properties

WHITE CRYSTALLINE POWDER

Uses

3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:

• to inhibit collagen cross-linking during microtissue formation and culture
• in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay
• in lysyl oxidase (LOX) activity assay
• to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids

Definition

ChEBI: A fumarate salt prepared from beta-aminopropionitrile by reaction of one molecule of fumaric acid for every two molecules of beta-aminopropionitrile.

Biochem/physiol Actions

3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO, and CN-. See also NITRILES.