2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
- Product Name
- 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
- CAS No.
- 178306-51-9
- Chemical Name
- 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
- Synonyms
- Ambrisentan PI-2;2-Hydroxy-3-methoxy-3,3-diphenylpropanoicaci;2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID;2-hydroxy-3-methoxy-3,3-diphenyl-propionic acid;Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-;alpha-Hydroxy-beta-methoxy-beta-phenylbenzenepropanoic acid
- CBNumber
- CB42468790
- Molecular Formula
- C16H16O4
- Formula Weight
- 272.3
- MOL File
- 178306-51-9.mol
2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID Property
- Boiling point:
- 430℃
- Density
- 1.248
- Flash point:
- 158℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly)
- pka
- 3.24±0.28(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)
- InChIKey
- RQJWOLFMWKZKCJ-UHFFFAOYSA-N
- SMILES
- C(O)(C(O)=O)C(OC)(C1=CC=CC=C1)C1C=CC=CC=1
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H946108
- Product name
- 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- H946108
- Product name
- 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- H946108
- Product name
- 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid
- Packaging
- 5g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- H946108
- Product name
- 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid
- Packaging
- 10g
- Price
- $690
- Updated
- 2021/12/16
- Product number
- APN0000561
- Product name
- 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1585.35
- Updated
- 2021/12/16
2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID Chemical Properties,Usage,Production
Uses
2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid is used as a reactant in the preparation of mixed endothelin A and endothelin B selective receptor antagonist (dimethylpyrimidinyloxy)diphenylpropionic acids.
Synthesis
178306-47-3
178306-51-9
General procedure for the synthesis of 2-hydroxy-3-methoxy-3,3-diphenylmethylpropionic acid from methyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate: 500 g (1.75 mol) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylmethylpropionate was suspended in 1,000 mL of water with stirring and 950 mL (1.90 mol) of 2 mol/L sodium hydroxide solution. The reaction mixture was stirred at 100°C for 1 hour. Upon completion of the reaction, the solution was cooled to room temperature and 1,500 mL of tert-butyl methyl ether was added followed by 700 mL of 10% hydrochloric acid and stirred for 20 minutes to dissolve the precipitated solids. After performing a liquid-liquid separation, the organic layer was washed with 1,000 mL of water. To the organic layer, 1,200 mL of heptane was added and the solvent was removed by distillation under reduced pressure at 40 °C and 200 mmHg pressure to induce precipitation of crystals. Another 1,000 mL of heptane was added and the mixture was stirred at 0 °C for 1 hour. The crystals were collected by filtration and dried under reduced pressure at 40 °C for 7 h to give 431 g (91% yield) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid.
References
[1] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0040
[2] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 11
[3] Patent: WO2010/70658, 2010, A2. Location in patent: Page/Page column 18-19
[4] Patent: US2011/263854, 2011, A1. Location in patent: Page/Page column 8
[5] Organic Process Research and Development, 2001, vol. 5, # 1, p. 16 - 22
2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID manufacturers
- Product
- 2-hydroxy-3-Methoxy-3,3-diphenylpropanoic acid 178306-51-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2022-12-29
- Product
- Ambrisentan Impurity 5 178306-51-9
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 100000
- Release date
- 2025-03-28
- Product
- 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID 178306-51-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10