Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- Product Name
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- CAS No.
- 178306-47-3
- Chemical Name
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- Synonyms
- ALST-01;Ambrisentan PI-4;2-hydroxy-3-methoxy-3;3-diphenylpropanoic acid methyl ester;Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate;2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester;α-Hydroxy-β-Methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester;Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl e...;Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-, methyl ester;Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- CBNumber
- CB52077328
- Molecular Formula
- C17H18O4
- Formula Weight
- 286.32
- MOL File
- 178306-47-3.mol
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester Property
- Melting point:
- 96-98°C
- Boiling point:
- 440.7±40.0 °C(Predicted)
- Density
- 1.176
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 12.37±0.20(Predicted)
- color
- White to Off-White
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 055491
- Product name
- Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 055491
- Product name
- Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate
- Purity
- >95%
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 9357AA
- Product name
- Methyl2-hydroxy-3-methoxy-3,3-diphenylpropanoate
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
- Product number
- 055491
- Product name
- Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate
- Purity
- >95%
- Packaging
- 5g
- Price
- $266
- Updated
- 2021/12/16
- Product number
- CHM0149609
- Product name
- 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $671.75
- Updated
- 2021/12/16
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester Chemical Properties,Usage,Production
Uses
Ambrisentan intermediate.
Synthesis
67-56-1
76527-25-8
178306-47-3
1. 500 g (2.74 mol) of benzophenone was dissolved in 1200 mL of toluene and the reaction system was purged using nitrogen. Subsequently, 267 g (4.94 mol) of sodium methanol was added and stirred to form a suspension. 2. The suspension was cooled and 410 mL (4.68 mol) of methyl chloroacetate in toluene (300 mL) was slowly added dropwise over a period of 90 minutes, with the reaction temperature maintained at -8 to 4°C. The reaction temperature was maintained at -8 to 4°C. After the dropwise addition was completed, the reaction solution was cooled to 0°C and maintained for 1 hr. 3. 1000 mL of water was added and stirred for 15 minutes before liquid-liquid separation. The organic layer was washed with 1000mL of water. 4. The solvent was removed by distillation under reduced pressure and the resulting residue (methyl (RS)-3,3-diphenyl-2,3-epoxyacrylate) was dissolved in 1200 mL of methanol and cooled to 0°C. 5. A methanolic solution of 15 g (0.08 mol) of toluene sulfonic acid monohydrate (150 mL) was added slowly and dropwise over 30 min. The mixture was stirred at 0°C for 1.5 h. The precipitated crystals were collected by filtration. 6. The crystals were dissolved in 2500 mL of ethyl acetate and washed twice with 1000 mL of 5% aqueous sodium carbonate. 7. The solvent was removed by pressurized distillation and 1000 mL of hexane was added to the residue, suspended and stirred at room temperature for 1.5 hours, followed by stirring at 0°C for 1 hour. 8. The crystals were collected by filtration and dried under reduced pressure at 60 °C for 5 h to give 659 g (yield: 84%) of methyl (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionate.
References
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 11, p. 2123 - 2128
[2] Patent: JP5700378, 2015, B2. Location in patent: Paragraph 0062
[3] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0039
[4] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 10-11
[5] Patent: WO2010/70658, 2010, A2. Location in patent: Page/Page column 18
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester manufacturers
- Product
- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester 178306-47-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2022-12-29
- Product
- Ambrisentan Impurity 178306-47-3
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 100000
- Release date
- 2025-03-28
- Product
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester 178306-47-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10