DGAT-1 inhibitor

ChemicalBook > CAS DataBase List > DGAT-1 inhibitor

Product Name: DGAT-1 inhibitor
CAS No.: 959122-11-3
Chemical Name: DGAT-1 inhibitor
Synonyms: CS-121;A922500;DGAT-1 inhibitor;DGAT-1 Inhibitor 4a;DGAT-1 Inhibitor, A 922500;DGAT-1 inhibitor USP/EP/BP;A922500(DGAT-1 Inhibitor 4a);DGAT-1 Inhibitor A922500 A-922500;DGAT-1 INHIBITOR 4A; A-922500; A922500;Diacyl glycerolacyltransferase 1 inhibitor
CBNumber: CB42470944
Molecular Formula: C26H24N2O4
Formula Weight: 428.48
MOL File: 959122-11-3.mol

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DGAT-1 inhibitor Property

Density: 1.323
storage temp.: -20°C
solubility: ≥21.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: Light yellow solid

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Safety

Hazard Codes: T,N
Risk Statements: 25-36-50
Safety Statements: 26-45-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A1737
Product name: A922500
Packaging: 1MG
Price: $57.5
Updated: 2023/06/20

Sigma-Aldrich

Product number: A1737
Product name: A922500
Packaging: 5MG
Price: $242
Updated: 2023/06/20

Sigma-Aldrich

Product number: A1737
Product name: A922500
Packaging: 10MG
Price: $413
Updated: 2023/06/20

Sigma-Aldrich

Product number: 252801
Product name: DGAT-1 Inhibitor, A 922500
Packaging: 5mg
Price: $298
Updated: 2022/05/15

Cayman Chemical

Product number: 10012708
Product name: A-922500
Purity: ≥95%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

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DGAT-1 inhibitor Chemical Properties,Usage,Production

Uses

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.

Definition

ChEBI: A 922500 is an aromatic ketone.

Biological Activity

Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.

Biochem/physiol Actions

The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.

DGAT-1 inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DGAT-1 inhibitor manufacturers

Career Henan Chemical Co

Product: (1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid 959122-11-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

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(1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid

DGAT-1 inhibitor

Diacyl glycerolacyltransferase 1 inhibitor

A922500

A922500(DGAT-1 Inhibitor 4a)

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DGAT-1 Inhibitor 4a

(1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid

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(1R,2R)-2-(4,-(3-phenylureido)-[1,1,-biphenyl]-4-carbonyl)cyclopentanecarboxylic acid

DGAT-1 Inhibitor, A 922500

CS-121

DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

DGAT-1 INHIBITOR 4A; A-922500; A922500

DGAT-1 inhibitor USP/EP/BP

DGAT-1 Inhibitor A922500 A-922500

(1R,2R)-2-(4'-(3-Phenylureido)-[1,1'-biphenyl]-4-carbonyl)cyclopentanecarboxylic acid

959122-11-3

Inhibitor

Inhibitors

APIs