ChemicalBook > CAS DataBase List > GSK1070916

GSK1070916

Product Name
GSK1070916
CAS No.
942918-07-2
Chemical Name
GSK1070916
Synonyms
CS-364;GSK1070916;GSK-1070916A;GSK1070916 USP/EP/BP;GSK-1070916 (NMI-900);GSK1070916;GSK 1070916;GSK-1070916?( GSK-1070916A);GSK1070916;GSK-1070916;GSK 1070916;GSK1070916 (NMI900 or GSK1070916 A);GSK-1070916 GSK1070916 NMI-900 NMI900
CBNumber
CB42485003
Molecular Formula
C30H33N7O
Formula Weight
507.63
MOL File
942918-07-2.mol
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GSK1070916 Property

Density 
1.21
storage temp. 
Store at -20°C
solubility 
≥25.4 mg/mL in DMSO
form 
solid
pka
13.17±0.40(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22953
Product name
GSK1070916
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
22953
Product name
GSK1070916
Purity
≥98%
Packaging
5mg
Price
$167
Updated
2024/03/01
Cayman Chemical
Product number
22953
Product name
GSK1070916
Purity
≥98%
Packaging
10mg
Price
$292
Updated
2024/03/01
Cayman Chemical
Product number
22953
Product name
GSK1070916
Purity
≥98%
Packaging
25mg
Price
$632
Updated
2024/03/01
TRC
Product number
G797455
Product name
GSK1070916
Packaging
5mg
Price
$125
Updated
2021/12/16
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GSK1070916 Chemical Properties,Usage,Production

Uses

GSK 1070916 is a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.

Definition

ChEBI: 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea is a member of pyrazoles and a ring assembly.

Biological Activity

gsk1070916 is a potent and selective inhibitor of aurora b/c kinase with ki values of 0.38nm and 1.5nm, respectively [1].gsk1070916 is a reversible atp-competitive inhibitor of aurora b and aurora c with ki values of 0.38nm and 1.5nm, respectively. the spa assay shows gsk1070916 has a good selectivity over aurora a. it inhibits aurora b with ic50 value of 5nm but 1259nm for aurora a. it is also reported that treatment of gsk1070916 suppresses cell proliferation in a549 human lung cancer cells with ec50 value of 7nm. moreover, both in vitro and in vivo assays demonstrate gsk1070916 can inhibit the phosphorylation of histone h3, which is a substrate of aurora b. gsk1070916 can also suppress tumor growth in mice with hl-60 tumor xenografts [1].

target

Aurora B

References

[1] adams nd, adams jl, burgess jl, chaudhari am, copeland ra, donatelli ca, drewry dh, fisher ke, hamajima t, hardwicke ma, huffman wf, koretke-brown kk, lai zv, mcdonald ob, nakamura h, newlander ka, oleykowski ca, parrish ca, patrick dr, plant r, sarpong ma, sasaki k, schmidt sj, silva dj, sutton d, tang j, thompson cs, tummino pj, wang jc, xiang h, yang j, dhanak d. discovery of gsk1070916, a potent and selective inhibitor of aurora b/c kinase. j med chem. 2010 may 27;53(10):3973-4001.

GSK1070916 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK1070916 Suppliers

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942918-07-2, GSK1070916Related Search:

Enzastaurin (LY317615) ZM 447439 MK-5108 (VX-689) Alisertib (MLN8237) Veliparib Barasertib (AZD1152-HQPA)

  • N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea
  • GSK1070916
  • 3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea
  • N'-[4-[4-[2-[3-[(DiMethylaMino)Methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl
  • GSK-1070916A
  • GSK1070916;GSK 1070916
  • CS-364
  • GSK1070916;GSK-1070916;GSK 1070916
  • Urea, N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl-
  • GSK1070916 USP/EP/BP
  • GSK1070916 (NMI900 or GSK1070916 A)
  • GSK-1070916 GSK1070916 NMI-900 NMI900
  • GSK-1070916?( GSK-1070916A)
  • GSK-1070916 (NMI-900)
  • 942918-07-2
  • Inhibitors
  • Inhibitor