2-(bromomethyl)-6-(trifluoromethyl)pyridine

Product Name: 2-(bromomethyl)-6-(trifluoromethyl)pyridine
CAS No.: 781637-62-5
Chemical Name: 2-(bromomethyl)-6-(trifluoromethyl)pyridine
Synonyms: 2-(bromomethyl)-6-(trifluoromethyl)pyridine;Pyridine, 2-(bromomethyl)-6-(trifluoromethyl)-
CBNumber: CB42485285
Molecular Formula: C7H5BrF3N
Formula Weight: 240.02
MOL File: 781637-62-5.mol

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2-(bromomethyl)-6-(trifluoromethyl)pyridine Property

Boiling point:: 190.1±35.0 °C(Predicted)
Density: 1.647±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -1.24±0.24(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB143623
Product name: 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
Packaging: 100mg
Price: $68
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143623
Product name: 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
Packaging: 250mg
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143623
Product name: 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
Packaging: 500mg
Price: $235
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143623
Product name: 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
Packaging: 1g
Price: $410
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0103554
Product name: 2-(BROMOMETHYL)-6-(TRIFLUOROMETHYL)PYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.01
Updated: 2021/12/16

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2-(bromomethyl)-6-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

1620-72-0

781637-62-5

General procedure for the synthesis of 2-(bromomethyl)-6-(trifluoromethyl)pyridine using 2-methyl-6-(trifluoromethyl)pyridine as starting material: 2-methyl-6-(trifluoromethyl)pyridine (100 mg, 0.620 mmol) was dissolved in carbon tetrachloride (CCl4, 3 mL), and N-bromosuccinimide (NBS, 110 mg, 0.620 mmol) and 1,1'-azobis(cyclohexanenitrile) (VAZO, 8 mg, 0.031 mmol). The reaction mixture was heated and stirred at 90 °C for 15 hours. After completion of the reaction, the reaction solution was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by medium pressure liquid chromatography (MPLC, hexane/ethyl acetate = 5:1) to afford 2-(bromomethyl)-6-(trifluoromethyl)pyridine as a white solid (42.5 mg, 28.4% yield).1H NMR (300 MHz, CDCl3) δ 4.60 (2H, s), 7.61 (1H, d), 7.68 (1H, d) , 7.90 (1H, t).

References

[1] Patent: WO2013/129879, 2013, A1. Location in patent: Page/Page column 50; 51
[2] Patent: US2015/166558, 2015, A1. Location in patent: Paragraph 0300; 0301; 0302

2-(bromomethyl)-6-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(bromomethyl)-6-(trifluoromethyl)pyridine Suppliers

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781637-62-5, 2-(bromomethyl)-6-(trifluoromethyl)pyridineRelated Search:

2-(bromomethyl)-6-(trifluoromethyl)pyridine

Pyridine, 2-(bromomethyl)-6-(trifluoromethyl)-

781637-62-5