Rpaf-ah
- Product Name
- Rpaf-ah
- CAS No.
- 208576-22-1
- Chemical Name
- Rpaf-ah
- Synonyms
- Pafase;Rpaf-ah;Epafipase;PAF-AH human;PAF 2-acylhydrolase;Paf acetylhydrolase;Epafipase [usan:inn];LDL-associated phospholipase A2;Deacetylase, 1-alkyl-2-acetyllecithin (human);2-acetyl-1-alkylglycerophosphocholine esterase
- CBNumber
- CB42493219
- Formula Weight
- 0
- MOL File
- Mol file
Rpaf-ah Property
- storage temp.
- -20°C
- form
- lyophilized
- color
- white
- biological source
- human
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SRP3136
- Product name
- PAF-AH human
- Purity
- recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
- Packaging
- 20μG
- Price
- $371
- Updated
- 2025/07/31
Rpaf-ah Chemical Properties,Usage,Production
Uses
Antiallergenic; antiasthmatic (PAF antagonist [PAF acetylhydrolasemphor.].
General Description
Recombinant PAF-AH is a 420 amino acid glycoprotein which migrates with an apparent molecular mass of 47-55kDa by SDS-PAGE analysis.
Biochem/physiol Actions
Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet activating factor acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL (low density lipoprotein) particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids. High levels of PAF-AH in plasma can be an indication of resistant hypertension. Polymorphism in PAF-AH gene at A379V might be linked with ischemic stroke susceptibility.
Rpaf-ah Preparation Products And Raw materials
Raw materials
Preparation Products
Rpaf-ah Suppliers
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