1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
Application- Product Name
- 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
- CAS No.
- 864770-82-1
- Chemical Name
- 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester
- Synonyms
- 1-Boc-3-methylindazole-5-boronic Acid Pinacol Ester;1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester;1-N-Boc-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3-Methyl-indazole;(1-(TERT-BUTOXYCARBONYL)-3-METHYL-1H-INDAZOL-5-YL)BORONIC ACID PINACOL ESTER;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;Tert-butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate;tert-butyl 3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate;3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester;1H-Indazole-1-carboxylic acid, 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
- CBNumber
- CB42499635
- Molecular Formula
- C19H27BN2O4
- Formula Weight
- 358.24
- MOL File
- 864770-82-1.mol
1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Property
- Boiling point:
- 476℃
- Density
- 1.12
- Flash point:
- 242℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB144070
- Product name
- tert-Butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FB144070
- Product name
- tert-Butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 8H60-1-FY
- Product name
- 1-N-Boc-3-methyl-indazole-5-boronic acid, pinacol ester
- Purity
- 97%
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 3554AC
- Product name
- 1-N-Boc-3-Methylindazole-5-boronicacidpinacolester
- Packaging
- 250mg
- Price
- $279
- Updated
- 2021/12/16
- Product number
- FB144070
- Product name
- tert-Butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
- Packaging
- 500mg
- Price
- $295
- Updated
- 2021/12/16
1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Chemical Properties,Usage,Production
Application
1-N-BOC-3-methylindazole-5-boronic acid pinacol ester is an organic synthesis intermediate and pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.
Synthesis
552331-49-4
73183-34-3
864770-82-1
Potassium acetate (4.73 g, 48.3 mmol) and Pd(dppf)Cl2 (0.66 g, 0.81 mmol) in anhydrous DMF (60 mL) were added to tert-butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate (5.00 g, 16.1 mmol) and pinacol ester of bisboronic acid (4.49 g, 17.7 mmol). The mixture was placed in a vial with a rubber-lined screw cap and degassed by three vacuum/nitrogen cycles. Subsequently, the suspension was heated with stirring at 100 °C for 2 h under nitrogen protection. Upon completion of the reaction, the mixture was cooled to room temperature, mixed with saturated aqueous sodium bicarbonate solution (100 mL) and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography using gradient elution with ethyl acetate/hexane (0% to 15%) to afford the target product tert-butyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate as an oil (5.55 g, 96% yield).LCMS (+APCI) m/z. 499 (M+H).
References
[1] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 24
[2] Patent: WO2005/85227, 2005, A1. Location in patent: Page/Page column 37; 76
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 673 - 678
[4] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 22-23
[5] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 23
1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester Suppliers
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 18602194589
- lincy-110@163.com
- Country
- China
- ProdList
- 863
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 716
- Advantage
- 55
- Tel
- 13564638271
- Fax
- 021-68948280
- shhjiang1977@163.com
- Country
- China
- ProdList
- 2987
- Advantage
- 55
View Lastest Price from 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester manufacturers
- Product
- 1-N-Boc-3-methyl-indazole-5-boronic acid pinacol ester 864770-82-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12