ChemicalBook > CAS DataBase List > SU 16f
SU 16f
- Product Name
- SU 16f
- CAS No.
- 251356-45-3
- Chemical Name
- SU 16f
- Synonyms
- SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
- CBNumber
- CB42501833
- Molecular Formula
- C24H22N2O3
- Formula Weight
- 386.44
- MOL File
- 251356-45-3.mol
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SU 16f Property
- Boiling point:
- 661.7±55.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO
- form
- Dark orange solid
- pka
- 4?+-.0.10(Predicted)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 521237
- Product name
- PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
- Packaging
- 5mg
- Price
- $294
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 19555
- Product name
- SU 16f
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19555
- Product name
- SU 16f
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19555
- Product name
- SU 16f
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $238
- Updated
- 2024/03/01
Tocris
- Product number
- 3304
- Product name
- SU16f
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $233
- Updated
- 2021/12/16
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SU 16f Chemical Properties,Usage,Production
Uses
SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor.
General Description
A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM).
storage
Store at RT
SU 16f Preparation Products And Raw materials
Raw materials
Preparation Products
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