ChemicalBook > CAS DataBase List > SU 16f

SU 16f

Product Name
SU 16f
CAS No.
251356-45-3
Chemical Name
SU 16f
Synonyms
SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-;3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
CBNumber
CB42501833
Molecular Formula
C24H22N2O3
Formula Weight
386.44
MOL File
251356-45-3.mol
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SU 16f Property

Boiling point:
661.7±55.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble to 100 mM in DMSO
form 
Dark orange solid
pka
4?+-.0.10(Predicted)
color 
Yellow to orange
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
521237
Product name
PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
Packaging
5mg
Price
$294
Updated
2023/06/20
Cayman Chemical
Product number
19555
Product name
SU 16f
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
19555
Product name
SU 16f
Purity
≥98%
Packaging
5mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
19555
Product name
SU 16f
Purity
≥98%
Packaging
10mg
Price
$238
Updated
2024/03/01
Tocris
Product number
3304
Product name
SU16f
Purity
≥98%(HPLC)
Packaging
10
Price
$233
Updated
2021/12/16
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SU 16f Chemical Properties,Usage,Production

Uses

SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor.

General Description

A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM).

storage

Store at RT

SU 16f Preparation Products And Raw materials

Raw materials

Preparation Products

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SU 16f Suppliers

China 46 United Kingdom 1 United States 10 Global 57
VDM Biochemicals
Tel
0330-2528181
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0330-2528171
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sales@vdmbio.com
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United States
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
ApexBio Technology
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sales@apexbt.com
Country
United States
ProdList
6251
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58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80
MedChemExpress
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sales@medchemexpress.com
Country
United States
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6398
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Riedel-de Haen AG
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United States
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6773
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Matrix Scientific
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sales@matrixscientific.com
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United States
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6632
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80

251356-45-3, SU 16fRelated Search:


  • 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
  • (Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
  • SU 16f
  • PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
  • 1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
  • 3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
  • 251356-45-3
  • Angiogenesis and Metastasis