(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

ChemicalBook > CAS DataBase List > (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

Product Name: (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol
CAS No.: 106083-71-0
Chemical Name: (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol
Synonyms: GW 353162;GW-353162A;BW-306U;Bupropion Morpholinol IMpurity;SS-hydroxybupropion hydrochloride;Bupropion Morpholinol (2S,3S)-Isomer;(2S,3S)-Hydroxybupropion hydrochloride;Bupropion Morpholinol IMpurity (HCl Salt);(2S,3S)-Hydroxybupropion hydrochloride >=98% (HPLC);(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol;(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol
CBNumber: CB42502638
Molecular Formula: C13H19Cl2NO2
Formula Weight: 292.2
MOL File: 106083-71-0.mol

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(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Property

storage temp.: -20°C
solubility: DMSO: ≥12mg/mL
form: powder
color: white to tan

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H3167
Product name: (2S,3S)-Hydroxybupropion hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Sigma-Aldrich

Product number: H3167
Product name: (2S,3S)-Hydroxybupropion hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $592
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0004715
Product name: GW-353162A
Purity: 95.00%
Packaging: 25MG
Price: $1029.63
Updated: 2021/12/16

ChemScene

Product number: CS-3815
Product name: Radafaxine(hydrochloride)
Purity: 99.88%
Packaging: 10mg
Price: $192
Updated: 2021/12/16

ChemScene

Product number: CS-3815
Product name: Radafaxine(hydrochloride)
Purity: 99.88%
Packaging: 5mg
Price: $102
Updated: 2021/12/16

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(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Chemical Properties,Usage,Production

Uses

Antidepressant; antianxiety.

General Description

(2S,3S)-hydroxybupropion is a major metabolite of bupropion.

Biochem/physiol Actions

(2S,3S)-hydroxybupropion is a dopamine transporter (DAT) and norepinephrine transporter (NET) transporters inhibitor and nicotinic acetylcholine receptor (nAChR) family modulator. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in nicotine-dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of nicotine reward in mice.

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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106083-71-0, (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-olRelated Search:

Bupropion 2-(TERT-BUTYLAMINO)PROPIOPHENONE HYDROCHLORIDE 2-(tert-ButylaMino)-3',5'-chloropropiophenone hydrochloride 1-(3-Chlorophenyl)-2-hydroxy-1-propanone Bupropion Hydrochloride Bupropion Hydrochloride Related Compound B (15 mg) (2-(tert-butylamino)-3'-bromopropiophenone hydrochloride) 2-(tert-ButylaMino)-3',4'-chloropropiophenone hydrochloride Bupropion Hydrochloride Related Compound A (15 mg) (2-(tert-butylamino)-4'-chloropropiophenone hydrochloride) 2-(tert-ButylaMino)-2'-chloropropiophenone Hydrochloride (R,R)-Hydroxy Bupropion

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride

(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride

(2S,3S)-Hydroxybupropion hydrochloride

GW 353162

SS-hydroxybupropion hydrochloride

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

Bupropion Morpholinol (2S,3S)-Isomer

Bupropion Morpholinol IMpurity

Bupropion Morpholinol IMpurity (HCl Salt)

GW-353162A;BW-306U

(2S,3S)-Hydroxybupropion hydrochloride >=98% (HPLC)

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

106083-71-0