2-Fluoro-6-methylphenylboronic acid
- Product Name
- 2-Fluoro-6-methylphenylboronic acid
- CAS No.
- 887471-69-4
- Chemical Name
- 2-Fluoro-6-methylphenylboronic acid
- Synonyms
- 2-iodo-3-(methoxymethyl)pyridine;2-Fluoro-6-methylphenylboronic acid;(2-Fluoro-6-methylphenyl)boronic acid 97%;Boronic acid, B-(2-fluoro-6-methylphenyl)-;(2-fluoro-6-methylphenyl)boronic acid(WX900172);(2-Fluoro-6-methylphenyl)boronic acid - [F88944]
- CBNumber
- CB42503756
- Molecular Formula
- C7H8BFO2
- Formula Weight
- 153.95
- MOL File
- 887471-69-4.mol
2-Fluoro-6-methylphenylboronic acid Property
- Boiling point:
- 285.9±50.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 8.40±0.58(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F596510
- Product name
- 2-Fluoro-6-methylphenylboronicacid
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- F596510
- Product name
- 2-Fluoro-6-methylphenylboronicacid
- Packaging
- 500mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- F596510
- Product name
- 2-Fluoro-6-methylphenylboronicacid
- Packaging
- 1g
- Price
- $825
- Updated
- 2021/12/16
- Product number
- 35812
- Product name
- (2-Fluoro-6-methylphenyl)boronicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $880
- Updated
- 2021/12/16
- Product number
- BOR0006420
- Product name
- (2-FLUORO-6-METHYLPHENYL)BORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $975.45
- Updated
- 2021/12/16
2-Fluoro-6-methylphenylboronic acid Chemical Properties,Usage,Production
Uses
2-Fluoro-6-methylphenylboronic acid is used in biochemical methods of study as a reagent for fluorinated boronic acid-appended pyridinium salts and 19F NMR Spectroscopy for diol sensing.
Synthesis
59907-13-0
887471-69-4
General procedure for the synthesis of (2-fluoro-6-methylphenyl)boronic acid from 2-bromo-1-fluoro-3-methylbenzene: 2-bromo-1-fluoro-3-methylbenzene (300 mg, 1.59 mmol) was dissolved in anhydrous ether (3 mL), and triisopropyl borate (6.2 mL, 26.7 mmol) was added. The reaction mixture was cooled to -78 °C under argon protection. A tert-butyl lithium solution (1.7 M in pentane, 2.2 mL, 3.74 mmol) was added slowly and dropwise. The reaction system was then warmed to -10 °C and stirred at this temperature for 30 min. Upon completion of the reaction, 5N hydrochloric acid (2 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was extracted twice with diisopropyl ether and the organic layers were combined and alkalized with 2N sodium hydroxide solution. The aqueous phase was adjusted to pH 1 with hydrochloric acid and extracted twice with ether. The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give (2-fluoro-6-methylphenyl)boronic acid (117 mg, 43% yield) as a white solid. lRMS (m/z): 155 (M + 1)+.
References
[1] Patent: EP2738172, 2014, A1. Location in patent: Paragraph 0155
[2] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 43
2-Fluoro-6-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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