1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1206640-82-5
Chemical Name: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 1-(Difluoromethyl)pyrazole-4-boronic aci;1-(Difluoromethyl)pyrazole-4-boronic acid pinacol ester;1-(Difluoromethyl)-1H-pyrazole-4-boronic acid pinacol ester;1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan;(1-(DIFLUOROMETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;1-(difluoroMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-y;1-(difluoromethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1H-Pyrazole, 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB42514877
Molecular Formula: C10H15BF2N2O2
Formula Weight: 244.05
MOL File: 1206640-82-5.mol

More

Less

1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:: 294.9±40.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -1.01±0.19(Predicted)
form: solid
color: White
InChI: InChI=1S/C10H15BF2N2O2/c1-9(2)10(3,4)17-11(16-9)7-5-14-15(6-7)8(12)13/h5-6,8H,1-4H3
InChIKey: SACVSUQLLHEZLY-UHFFFAOYSA-N
SMILES: N1(C(F)F)C=C(B2OC(C)(C)C(C)(C)O2)C=N1

More

Less

Safety

HS Code: 2933199090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: D447573
Product name: 1-(Difluoromethyl)pyrazole-4-boronicacidpinacolester
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D447573
Product name: 1-(Difluoromethyl)pyrazole-4-boronicacidpinacolester
Packaging: 250mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: Z3972
Product name: 1-(Difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 1g
Price: $87
Updated: 2021/12/16

ChemScene

Product number: CS-W000398
Product name: 1-(Difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: ≥98.0%
Packaging: 5g
Price: $103
Updated: 2021/12/16

ChemScene

Product number: CS-W000398
Product name: 1-(Difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: ≥98.0%
Packaging: 1g
Price: $27
Updated: 2021/12/16

More

Less

1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Synthesis

269410-08-4

1895-39-2

1206640-82-5

Step 1: Synthesis of 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole To a 100 mL round bottom flask was added 4-pyrazole boronic acid pinacol ester (1.0 g, 5.15 mmol), 18-crown-6 (0.27 g, 1.03 mmol) and anhydrous acetonitrile (25 mL). The mixture was stirred until a colorless homogeneous solution was formed and then sodium difluorochloroacetate (0.94 g, 6.18 mmol) was added. The reaction mixture was heated to reflux and held for 18 hours. After completion of the reaction, the mixture was cooled to room temperature. Insoluble solids were removed by filtration through a diatomaceous earth pad and the filter cake was washed with ethyl acetate (3 x 20 mL). The filtrate and washings were combined, filtered through a hydrophobic glassine and concentrated under reduced pressure to give a light yellow oily crude product. The crude product was purified by fast silica gel column chromatography (gradient elution, hexane to 33% ethyl acetate/isohexane) to afford 1-(difluoromethyl)-4-boronic acid pinacol ester-based-1H-pyrazole as a colorless solid (1.06 g, 84% yield). The mass spectrum (electrospray positive ion mode) showed the molecular ion peak (M+H)+ consistent with the target compound.

References

[1] Patent: WO2014/159218, 2014, A1. Location in patent: Paragraph 00218
[2] Patent: WO2014/159224, 2014, A1. Location in patent: Paragraph 00256
[3] Patent: US2017/8889, 2017, A1. Location in patent: Paragraph 0324; 0325
[4] Patent: US2010/197651, 2010, A1. Location in patent: Page/Page column 84
[5] Patent: WO2014/1377, 2014, A1. Location in patent: Page/Page column 119; 120

1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

China 84 India 1 United Kingdom 1 United States 8 Global 94

Shanghai Rong Lin Medical Technology Co., Ltd.

Tel: 18602194589
Email: lincy-110@163.com
Country: China
ProdList: 863
Advantage: 58

Nanjing xiangrui technology co. LTD

Tel: 021-021-00000000 15715199582
Email: njrich168@163.com
Country: China
ProdList: 550
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
Country: China
ProdList: 991
Advantage: 62

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

More

Less

View Lastest Price from 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

Career Henan Chemical Co

Product: 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1206640-82-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

1206640-82-5, 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

1-(difluoromethyl)-1h-pyrazol-4-amine 4-BROMO-1-(DIFLUOROMETHYL)-1H-PYRAZOLE N-difluoroMenthyl-4-nitropyrazole (1-(Difluoromethyl)-1H-pyrazol-4-yl)boronic acid 1-(difluoromethyl)-1H-pyrazole 1-(difluoroMethyl)-4-iodo-1H-pyrazole

1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-(difluoroMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-y

1-(difluoromethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-(Difluoromethyl)pyrazole-4-boronic acid pinacol ester

(1-(DIFLUOROMETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER

1-(Difluoromethyl)pyrazole-4-boronic aci

1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

1-(Difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 97%

1H-Pyrazole, 1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

1-(Difluoromethyl)-1H-pyrazole-4-boronic acid pinacol ester

1-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan

1-(Difluoromethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [D17451]

1206640-82-5

206640-82-5

C10H15BF2N2O2