N-difluoroMenthyl-4-nitropyrazole
Application- Product Name
- N-difluoroMenthyl-4-nitropyrazole
- CAS No.
- 956477-64-8
- Chemical Name
- N-difluoroMenthyl-4-nitropyrazole
- Synonyms
- (Difluoromethyl)N-difluoroMenthyl-4-nitropyrazole;1-(Difluoromethyl)-4-nitropyrazole;1H-Pyrazole, 1-(difluoromethyl)-4-nitro-;Methyl 3,4-dihydroxy-2,5-diMethylbenzoate
- CBNumber
- CB52711396
- Molecular Formula
- C4H3F2N3O2
- Formula Weight
- 163.08
- MOL File
- 956477-64-8.mol
N-difluoroMenthyl-4-nitropyrazole Property
- Boiling point:
- 87-90℃ (20 Torr)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -5.19±0.19(Predicted)
- Appearance
- Light yellow to yellow Liquid
- InChI
- InChI=1S/C4H3F2N3O2/c5-4(6)8-2-3(1-7-8)9(10)11/h1-2,4H
- InChIKey
- VCURCUIEDUUUEA-UHFFFAOYSA-N
- SMILES
- N1(C(F)F)C=C([N+]([O-])=O)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D590943
- Product name
- 1-(difluoromethyl)-4-nitro-1H-pyrazole
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D590943
- Product name
- 1-(difluoromethyl)-4-nitro-1H-pyrazole
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 1460AL
- Product name
- 1-(Difluoromethyl)-4-nitro-1H-pyrazole
- Packaging
- 5g
- Price
- $444
- Updated
- 2021/12/16
- Product number
- 1460AL
- Product name
- 1-(Difluoromethyl)-4-nitro-1H-pyrazole
- Packaging
- 10g
- Price
- $657
- Updated
- 2021/12/16
- Product number
- 956477648
- Product name
- 1-(Difluoromethyl)-4-nitro-1H-pyrazole
- Packaging
- 10g
- Price
- $820.08
- Updated
- 2021/12/16
N-difluoroMenthyl-4-nitropyrazole Chemical Properties,Usage,Production
Application
1-Difluoromethyl-4-nitropyrazole is an organic intermediate that can be prepared in one step from 4-nitro-1H-pyrazole and sodium 2-chloro-2,2-difluoroacetate, or from the nitration of 1-difluoromethylpyrazole.
Synthesis
2075-46-9
1895-39-2
956477-64-8
General procedure for the synthesis of 1-(difluoromethyl)-4-nitro-1H-pyrazole from 4-nitropyrazole and sodium difluorochloroacetate: 4-nitro-1H-pyrazole (5.00 g, 44.2 mmol) was added by suspending cesium carbonate (Cs2CO3, 14.41 g, 44.2 mmol) in N,N-dimethylformamide (DMF, 40 mL). The mixture was heated to 120 °C and held for 5 min, followed by addition of solid sodium 2-chloro-2,2-difluoroacetate (13.48 g, 88 mmol) in 10 portions over 20 min. Heating was continued for 10 min and the reaction was completed. The reaction mixture was transferred to a partition funnel containing 100 mL of water and extracted with ether (Et2O, 2 x 50 mL). The organic layers were combined and concentrated. The crude product was purified by normal-phase chromatography using a gradient elution with hexane/ethyl acetate (EtOAc) to afford 1-(difluoromethyl)-4-nitro-1H-pyrazole (6.99 g, 42.9 mmol, 97% yield) as a clear, colorless oil.1H NMR (500 MHz, CDCl3) δ 8.58 (s, 1H), 8.22 (s, 1H) 7.39-7.05 (t, J = 60 Hz, 1H).
References
[1] Patent: WO2015/116886, 2015, A1. Location in patent: Page/Page column 200
[2] Patent: WO2015/116882, 2015, A1. Location in patent: Page/Page column 84; 88
[3] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00558; 00559; 00560
[4] Patent: WO2017/74832, 2017, A1. Location in patent: Page/Page column 202
N-difluoroMenthyl-4-nitropyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-difluoroMenthyl-4-nitropyrazole manufacturers
- Product
- N-difluoroMenthyl-4-nitropyrazole 956477-64-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-12-02
- Product
- N-difluoroMenthyl-4-nitropyrazole 956477-64-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%
- Supply Ability
- 1000kh
- Release date
- 2025-12-02
- Product
- N-difluoroMenthyl-4-nitropyrazole 956477-64-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18