AOD 9604 Property

Density 

1.49

storage temp. 

Store at -20°C

solubility 

DMSO: Slightly soluble

pka

3.49±0.10(Predicted)

InChI

InChI=1/C78H123N23O23S2/c1-9-41(8)62(101-68(115)47(18-14-28-86-78(83)84)91-69(116)50(29-38(2)3)95-63(110)45(79)30-43-19-21-44(104)22-20-43)75(122)100-61(40(6)7)74(121)94-49(23-25-56(80)105)67(114)98-55-37-126-125-36-54(65(112)88-32-57(106)89-51(76(123)124)31-42-15-11-10-12-16-42)97-70(117)52(34-102)90-58(107)33-87-64(111)48(24-26-59(108)109)93-73(120)60(39(4)5)99-71(118)53(35-103)96-66(113)46(92-72(55)119)17-13-27-85-77(81)82/h10-12,15-16,19-22,38-41,45-55,60-62,102-104H,9,13-14,17-18,23-37,79H2,1-8H3,(H2,80,105)(H,87,111)(H,88,112)(H,89,106)(H,90,107)(H,91,116)(H,92,119)(H,93,120)(H,94,121)(H,95,110)(H,96,113)(H,97,117)(H,98,114)(H,99,118)(H,100,122)(H,101,115)(H,108,109)(H,123,124)(H4,81,82,85)(H4,83,84,86)/t41-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55+,60-,61-,62-/s3

InChIKey

GVIYUKXRXPXMQM-LGMPOEIYNA-N

SMILES

N([C@@H]1CSSC[C@H](NC([C@@H](NC(CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@]([H])(C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC1=O)=O)CO)=O)C(=O)NCC(=O)N[C@H](C(=O)O)CC1C=CC=CC=1)C(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@]([H])([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1 |&1:1,6,9,16,25,33,39,61,74,83,90,92,99,110,118,r|

Hazard and Precautionary Statements (GHS)

AOD 9604 Chemical Properties,Usage,Production

Description

AOD9604 is a peptide fragment (Fragment 177-191) of the C-terminus of Human Growth Hormone to which a tyrosine is added at the N-terminal end. AOD stands for “Anti-Obesity Drug”. This peptide has an amino acid sequence that mimics the lip lytic region of human growth hormone (the region of this hormone thought to be responsible for burning fat) and it has been promoted variously as a weight loss supplement, as an aid to muscle and cartilage repair, and a treatment for osteoarthritis by its manufacturers. Studies have suggested that AOD9604 is more effective than its predecessor AOD9401. Recent clinical research studies have shown that AOD9604 did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people.

How it works

AOD-9604, also known as Tyr-hGH Frag 176-191 has been proven to have a strong fat burning capacity, without creating a desire to overeat. It doesn't affect blood sugar or tissue growth. (Heffernan 2001 Heffernan 2001, Ng 2000). AOD-9604 activates degradation and fat burning (oxidation), by a method that doesn't use hGH receptor. It has its own mechanism of action independent of hGH. Studies on rodents, pigs, dogs & humans have identified AOD-9604 mechanism where it triggers fat release from the obese fat cells predominantly and works to reduce the accumulation of new fat in fat cells as well as increasing fat burning. What is extraordinary about the AOD-9604 is its ability to reduce abdominal fat stores.
The second most potent fat loss peptide is CJC-1295, since it leads to the increase in overall GH levels in the body (the opposite of what happens typically as individual age) This explains one of the reasons people have tended to gain fat as they get older. If your only goal is fat loss, it's usually best to avoid using products GHRP (GHRP-6, GHRP-2 or GHRH’s) because they may give you the side effects of increased hunger and raised cortisol. AOD-9604 does not increase hunger or raise cortisol.

Benefits

Reduces Body Fat
Triggers fat release from obese fat cells predominantly more than lean ones
Mimics the way natural growth hormone regulates fat metabolism
No adverse effects on blood sugar or growth
AOD-9604 stimulates lipolysis
Inhibits lipogenesis that's the transformation of non-fatty foods into body fat
AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.

Health Effects

In addition to its fat loss properties, studies show that this peptide can also treat osteoarthritis, as well as promote bone and cartilage repair.
Research in rats shows that AOD9604 injections directly into arthritic joints can help improve pain, quality of life, and lessen disability. The clinical exams indicate that AOD 9604 therapy is effective in reducing joint dysfunction and may work as a preventative as well as a treatment.
There's also evidence to suggest that AOD-9604 can directly reduce the risk of heart disease. Though fat reduction plays a role, scientists believe it is also due to the way this peptide affects the metabolism.
Clearly, the research on AOD 9604 is fascinating and looks highly promising to be an available drug in years to come. Thanks to its minimal side effects, scientists believe this to be the weight loss drug of the future.

Safety Profile

Studies have shown that AOD 9604 has a very excellent safety profile, especially that it shows no risk to any health condition when used through injection.

Clinical claims and research

During the 90s, researchers from Monash University in Australia found that growth hormone (GH) was responsible for controlling the effects of AOD 9604. In clinical trials, the overall goal of the research was to find an anti-obesity drug that could burn fats without promoting muscle growth. In doing so, researchers found that AOD 9604 had the ability to：
Decrease the development of new fat.
Regulate the body's metabolism.
Stimulate the release of fats from fat cells.
Help treat osteoarthritis and bone repair.
In other clinical trials, patients were shown to experience less fatigue and had more endurance to exercise. Patients suffering from obesity also reported feeling less hungry and were found to eat less when using AOD 9604.

Regulations

The U.S. Food & Drug Administration recently assigned Human GRAS status to AOD 9604, which is listed under the Generally Recognized As Safe (GRAS) program. This designation identifies any food additive as safe when used as intended, per the Federal Food, Drug, and Cosmetic Act. This peptide is extremely safe, and there are no known health risks associated with AOD 9604 injections, especially when compared to traditional hormone-based weight loss treatments.