Melanotan 1
Features- Product Name
- Melanotan 1
- CAS No.
- 75921-69-6
- Chemical Name
- Melanotan 1
- Synonyms
- NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
- CBNumber
- CB4252333
- Molecular Formula
- C78H111N21O19
- Formula Weight
- 1646.85
- MOL File
- 75921-69-6.mol
Melanotan 1 Property
- Density
- 1.46±0.1 g/cm3(Predicted)
- RTECS
- OS1830200
- storage temp.
- −20°C
- pka
- 4.43±0.10(Predicted)
- form
- Solid
- Water Solubility
- Soluble to 0.60 mg/ml in sterile water
- Sequence
- Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- InChIKey
- UAHFGYDRQSXQEB-LEBBXHLNSA-N
- CAS DataBase Reference
- 75921-69-6(CAS DataBase Reference)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- M8764
- Product name
- [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt
- Purity
- ≥95% (HPLC)
- Packaging
- 1mg
- Price
- $145.8
- Updated
- 2024/03/01
- Product number
- J66191
- Product name
- [Nle<sup>4</sup>, D-Phe<sup>7</sup>] alpha-Melanocyte Stimulating Hormone amide trifluoroacetate salt
- Packaging
- 1mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 3013
- Product name
- [Nle4,D-phe7]-alpha-MSH
- Packaging
- 1
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 256004
- Product name
- [Nle4,D-Phe7]-α-MSH
- Packaging
- 1mg
- Price
- $432
- Updated
- 2021/12/16
- Product number
- FM39599
- Product name
- Melanotan 1
- Packaging
- 5mg
- Price
- $456
- Updated
- 2021/12/16
Melanotan 1 Chemical Properties,Usage,Production
Features
Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.
Uses
Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.
Definition
ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.
General Description
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.
Biochem/physiol Actions
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.
Side effects
The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.
storage
Store at -20°C
Melanotan 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Melanotan 1 manufacturers
- Product
- Melanotan 1 75921-69-6
- Price
- US $30.00/box
- Min. Order
- 1box
- Purity
- 98%
- Supply Ability
- 2000box
- Release date
- 2024-03-21
- Product
- MT1 75921-69-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10T
- Release date
- 2024-01-10
- Product
- Melanotan 1 75921-69-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-03-26