Melanotan-1

Features

Product Name: Melanotan-1
CAS No.: 75921-69-6
Chemical Name: Melanotan-1
Synonyms: NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
CBNumber: CB4252333
Molecular Formula: C78H111N21O19
Formula Weight: 1646.85
MOL File: 75921-69-6.mol

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Melanotan-1 Property

Density: 1.46±0.1 g/cm3(Predicted)
RTECS: OS1830200
storage temp.: −20°C
solubility: 0.1% aqueous TFA: 1.00-1.04mg/mL, clear, colorless
pka: 4.43±0.10(Predicted)
form: Solid
color: White to off-white
biological source: synthetic (organic)
Water Solubility: Soluble to 0.60 mg/ml in sterile water
Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey: UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference: 75921-69-6(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M8764
Product name: [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $243.67
Updated: 2025/07/31

Tocris

Product number: 3013
Product name: [Nle4,D-phe7]-alpha-MSH
Packaging: 1
Price: $184
Updated: 2021/12/16

Usbiological

Product number: 256004
Product name: [Nle4,D-Phe7]-α-MSH
Packaging: 1mg
Price: $432
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM39599
Product name: Melanotan 1
Packaging: 5mg
Price: $456
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000201
Product name: MELANOTAN I
Purity: 95.00%
Packaging: 0.5MG
Price: $475
Updated: 2021/12/16

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Melanotan-1 Chemical Properties,Usage,Production

Features

Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Definition

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.

References

[1] Robert T Dorr. “Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.” Archives of dermatology 140 7 (2004): 827–35.

Origin

Melanotan-1, an alpha MSH analog (Nle4DPhe7-Melanocyte-Stimulating Hormone), is a potent melanocortin developed in the 1980s. Melanotan 2 is a shorter cyclic variant of Melanotan 1 produced in the 1990s. Melanotan 2 was found to increase skin pigmentation at lower cumulative doses than Melanotan 1. However, in clinical trials it was found to have more side effects including nausea somnolence and penile erections[1].

General Description

Melanotan-1 stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

storage

Store at -20°C

Melanotan-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Melanotan-1 Suppliers

China 249 France 1 Germany 2 India 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 4 United States 27 Global 287

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 2923
Advantage: 58

Shanghai HongTide Biotechnology Co.,Ltd.

Tel: 15318089928
Email: alex@hanhonggroup.com
Country: China
ProdList: 4604
Advantage: 58

Sichuan Takele Biotechnology Co., Ltd.

Tel: +86-028-64348587 15680781153
Email: sales@takelepeptide.com
Country: China
ProdList: 86
Advantage: 58

Phygene

Tel: 18059081430
Email: 2070812664@qq.com
Country: China
ProdList: 1232
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

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View Lastest Price from Melanotan-1 manufacturers

Shandong Hanjiang Chemical Co., Ltd

Product: Melanotan-1 75921-69-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1T
Release date: 2025-10-02

Hebei Lutong Import and Export Co., Ltd

Product: MT1 75921-69-6
Price: US $50.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-24

Shaanxi Dideu Medichem Co. Ltd

Product: MelanotanI 75921-69-6
Price: US $49.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2025-09-16

75921-69-6, Melanotan-1 Related Search:

D-Phenylalanine Diethylstilbestrol Melanotan Ⅱ Actate,MelanotanⅡAcetate,Melanotan-II(MT-II),Melanotan II acetate salt,Mt-Ii(Melanotan),Melanotan 2,Melanotan Ц,MELANOTAN II ALPHA-MSH Melanotan II）,MT-I (a MSH) ALPHA-MSH Melanotan,alpha-MSH Melanotan II acetate AC-LYS-PRO-VAL-NH2 MELANOTAN II, MT-Ⅱ Melanotan 1 [Nle4, D-Phe7]alfa-MSH, Melanotan I MELANOTAN II TRIFLUOROACETATE SALT Melanotan Ⅱ MelanotanⅠ(α-MSH) Melanotan I acetate AC-SYS(NLE)EH(D-PHE)RWGKPVK(BIOTIN)-AMIDE

[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE

(NLE4,D-PHE7)-ALPHA-MSH

[Nle4,D-Phe7]α-MSH

Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2

N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2

[Nle4,DPhe7] a-MSH, amide

[Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ

[Nle4, D-Phe7]-α-MSH, amide

[Nle4]-α-MSH, amide

(Nle4,D-Phe7)-α-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647

(Nle4,D-Phe7)-a-MSH

AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647

NLE4, D-PHE7 .ALPHA.-MSH, NDP-MSH, MELANOTAN I

Melanotan Ⅰ Acetate

[Nle4, D-Phe7] α-MSH NDP-MSH Melanotan Ⅰ

[Nle4,D-Phe7] α -MSH NDP-MSH Melanotan I

alpha-melanotropin, [Nle3,D-Phe7], trifluoroacetate

Melanotan II(10mg) /Mt-2 for Tanning Melanotan 2 CAS NO.75921-69-6 CAS NO.75921-69-6

Afamelanotide

[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone (MSH), amide

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt

a-Melanotropin (swine),4-L-norleucine-7-D-phenylalanine-

[NLE4, D-PHE7]-ALPHA-MSH, AMIDE

[NLE4,D-PHE7]-ALPHA-MELANOCYTE-STIMULATING HORMONE

[NLE4,DPHE7] ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE

NDP-MSHAC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2

NDP-MSH

Melanotan ① Acetate

[NLE4, DPHE7] A-MSH, AMIDE; MELANOTAN Ⅰ

Melanotan Ⅰ

MELANOTAN I

AC-SYS-NLE-EHFRWGKPV-NH2

AC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2

NLE-4-D-PHE-7-A-MELANOCYTE*STIMULATING H ORMONE

[Nle4,D-Phe7]-MSHNDP-MSH

[Nle4,D-Phe7] a-Melanocyte stimulating hormone,amide

[nle4, d-phe7]-α-melanocyte stimulating hormone trifluoroacetate salt

MSH, 4-Nle-7-Phe-alpha-

Melanotan I Acetate MelanotanⅠ(α-MSH)

4-Nle-7-phe-alpha-msh

4-Norleucyl-7-phenylalanine-alpha-msh

Melanotan-1

Melanotropin

[Nle4, D-Phe7]-α-Melanocyte stimulating hormone trifluoroacetate salt, ≥95% (HPLC)

N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-a-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide

α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-

Melanotan-1 USP/EP/BP

4-L-norleucine-7-D-phenylalanine-α-Melanotropin

Melanotan 1 (MT1) acetate

(Nle4,D-Phe7)-α-MSH

MT I （Melanotan-1）

MT-I (Melanotan I)

Melanotan I (MT1) acetate

Melanotan I (Afamelanotide

CUV1647)

(Nle?,D-Phe?)-α-MSH trifluoroacetate salt

[Nle4, D-Phe7]-α-Melanocyte stimulating hormone trifluoroacetate sal

[Nle4]-α-MSH, amide