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ChemicalBook > CAS DataBase List > Melanotan 1

Melanotan 1

Features
Product Name
Melanotan 1
CAS No.
75921-69-6
Chemical Name
Melanotan 1
Synonyms
NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
CBNumber
CB4252333
Molecular Formula
C78H111N21O19
Formula Weight
1646.85
MOL File
75921-69-6.mol
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Melanotan 1 Property

Density 
1.46±0.1 g/cm3(Predicted)
RTECS 
OS1830200
storage temp. 
−20°C
pka
4.43±0.10(Predicted)
form 
Solid
Water Solubility 
Soluble to 0.60 mg/ml in sterile water
Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey
UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference
75921-69-6(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M8764
Product name
[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt
Purity
≥95% (HPLC)
Packaging
1mg
Price
$145.8
Updated
2024/03/01
Alfa Aesar
Product number
J66191
Product name
[Nle<sup>4</sup>, D-Phe<sup>7</sup>] alpha-Melanocyte Stimulating Hormone amide trifluoroacetate salt
Packaging
1mg
Price
$161
Updated
2024/03/01
Tocris
Product number
3013
Product name
[Nle4,D-phe7]-alpha-MSH
Packaging
1
Price
$184
Updated
2021/12/16
Usbiological
Product number
256004
Product name
[Nle4,D-Phe7]-&alpha;-MSH
Packaging
1mg
Price
$432
Updated
2021/12/16
Biosynth Carbosynth
Product number
FM39599
Product name
Melanotan 1
Packaging
5mg
Price
$456
Updated
2021/12/16
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Melanotan 1 Chemical Properties,Usage,Production

Features

Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Definition

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.

General Description

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

storage

Store at -20°C

Melanotan 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Melanotan 1 Suppliers

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921 13355716090
Email
Sales@gotopbio.com
Country
China
ProdList
2807
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
19961912513
Email
sales@hongtide.com
Country
China
ProdList
4476
Advantage
58
Sichuan Takele Biotechnology Co., Ltd.
Tel
+86-028-64348587 15680781153
Email
sales@takelepeptide.com
Country
China
ProdList
91
Advantage
58
Phygene
Tel
18059081430
Email
2070812664@qq.com
Country
China
ProdList
1232
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4531
Advantage
62
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View Lastest Price from Melanotan 1 manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Melanotan 1 75921-69-6
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
2000box
Release date
2024-03-21
Shandong Hanjiang Chemical Co., Ltd
Product
MT1 75921-69-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-10
Dorne Chemical Technology co. LTD
Product
Melanotan 1 75921-69-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26

75921-69-6, Melanotan 1Related Search:


  • [NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE
  • (NLE4,D-PHE7)-ALPHA-MSH
  • [Nle4,D-Phe7]α-MSH
  • Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2
  • N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2
  • [Nle4,DPhe7] a-MSH, amide
  • [Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ
  • [Nle4, D-Phe7]-α-MSH, amide
  • [Nle4]-α-MSH, amide
  • (Nle4,D-Phe7)-α-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647
  • (Nle4,D-Phe7)-a-MSH
  • AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647
  • NLE4, D-PHE7 .ALPHA.-MSH, NDP-MSH, MELANOTAN I
  • Melanotan Ⅰ Acetate
  • [Nle4, D-Phe7] α-MSH NDP-MSH Melanotan Ⅰ
  • [Nle4,D-Phe7] α -MSH NDP-MSH Melanotan I
  • alpha-melanotropin, [Nle3,D-Phe7], trifluoroacetate
  • Melanotan II(10mg) /Mt-2 for Tanning Melanotan 2 CAS NO.75921-69-6 CAS NO.75921-69-6
  • Afamelanotide
  • [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone (MSH), amide
  • Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt
  • a-Melanotropin (swine),4-L-norleucine-7-D-phenylalanine-
  • Afamelanotide acetate
  • [NLE4, D-PHE7]-ALPHA-MSH, AMIDE
  • [NLE4,D-PHE7]-ALPHA-MELANOCYTE-STIMULATING HORMONE
  • [NLE4,DPHE7] ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE
  • NDP-MSHAC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2
  • NDP-MSH
  • Melanotan ① Acetate
  • [NLE4, DPHE7] A-MSH, AMIDE; MELANOTAN Ⅰ
  • Melanotan Ⅰ
  • MELANOTAN I
  • AC-SYS-NLE-EHFRWGKPV-NH2
  • AC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2
  • NLE-4-D-PHE-7-A-MELANOCYTE*STIMULATING H ORMONE
  • [Nle4,D-Phe7]-MSHNDP-MSH
  • [Nle4,D-Phe7] a-Melanocyte stimulating hormone,amide
  • [nle4, d-phe7]-α-melanocyte stimulating hormone trifluoroacetate salt
  • MSH, 4-Nle-7-Phe-alpha-
  • Melanotan I Acetate MelanotanⅠ(α-MSH)
  • 4-Nle-7-phe-alpha-msh
  • 4-Norleucyl-7-phenylalanine-alpha-msh
  • Melanotan-1
  • Melanotropin
  • [Nle4, D-Phe7]-α-Melanocyte stimulating hormone trifluoroacetate salt, ≥95% (HPLC)
  • N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-a-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide
  • α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-
  • Melanotan-1 USP/EP/BP
  • 4-L-norleucine-7-D-phenylalanine-α-Melanotropin
  • Melanotan 1 (MT1) acetate
  • (Nle4,D-Phe7)-α-MSH
  • MT I (Melanotan-1)
  • MT-I (Melanotan I)
  • Melanotan I (MT1) acetate
  • [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt
  • Melanotan I (Afamelanotide
  • CUV1647)
  • α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-