Melanotan-1

ChemicalBook > CAS DataBase List > Melanotan-1

Features

Product Name: Melanotan-1
CAS No.: 75921-69-6
Chemical Name: Melanotan-1
Synonyms: NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
CBNumber: CB4252333
Molecular Formula: C78H111N21O19
Formula Weight: 1646.85
MOL File: 75921-69-6.mol

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Melanotan-1 Property

Density: 1.46±0.1 g/cm3(Predicted)
RTECS: OS1830200
storage temp.: −20°C
pka: 4.43±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Soluble to 0.60 mg/ml in sterile water
Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey: UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference: 75921-69-6(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M8764
Product name: [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $145.8
Updated: 2024/03/01

Alfa Aesar

Product number: J66191
Product name: [Nle<sup>4</sup>, D-Phe<sup>7</sup>] alpha-Melanocyte Stimulating Hormone amide trifluoroacetate salt
Packaging: 1mg
Price: $161
Updated: 2024/03/01

Tocris

Product number: 3013
Product name: [Nle4,D-phe7]-alpha-MSH
Packaging: 1
Price: $184
Updated: 2021/12/16

Usbiological

Product number: 256004
Product name: [Nle4,D-Phe7]-α-MSH
Packaging: 1mg
Price: $432
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM39599
Product name: Melanotan 1
Packaging: 5mg
Price: $456
Updated: 2021/12/16

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Melanotan-1 Chemical Properties,Usage,Production

Features

Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Definition

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.

Origin

Melanotan 1, an alpha MSH analog (Nle4DPhe7-Melanocyte-Stimulating Hormone), is a potent melanocortin developed in the 1980s. Melanotan 2 is a shorter cyclic variant of Melanotan 1 produced in the 1990s. Melanotan 2 was found to increase skin pigmentation at lower cumulative doses than Melanotan 1. However, in clinical trials it was found to have more side effects including nausea somnolence and penile erections[1].

References

[1] Robert T Dorr. “Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.” Archives of dermatology 140 7 (2004): 827–35.

General Description

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

storage

Store at -20°C

Melanotan-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Melanotan-1 manufacturers

Dorne Chemical Technology co. LTD

Product: Melanotan 1 75921-69-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Melanotan I 75921-69-6
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

hebei hongtan Biotechnology Co., Ltd

Product: Melanotan 1 75921-69-6
Price: US $30.00/box
Min. Order: 1box
Purity: 98%
Supply Ability: 2000box
Release date: 2024-03-21

75921-69-6, Melanotan-1 Related Search:

D-Phenylalanine Diethylstilbestrol Melanotan Ⅱ Actate,MelanotanⅡAcetate,Melanotan-II(MT-II),Melanotan II acetate salt,Mt-Ii(Melanotan),Melanotan 2,Melanotan Ц,MELANOTAN II ALPHA-MSH Melanotan II）,MT-I (a MSH) ALPHA-MSH Melanotan,alpha-MSH Melanotan II acetate AC-LYS-PRO-VAL-NH2 MELANOTAN II, MT-Ⅱ Melanotan 1 [Nle4, D-Phe7]alfa-MSH, Melanotan I MELANOTAN II TRIFLUOROACETATE SALT Melanotan Ⅱ MelanotanⅠ(α-MSH) Melanotan I acetate AC-SYS(NLE)EH(D-PHE)RWGKPVK(BIOTIN)-AMIDE

[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE

(NLE4,D-PHE7)-ALPHA-MSH

[Nle4,D-Phe7]α-MSH

Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2

N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2

[Nle4,DPhe7] a-MSH, amide

[Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ

[Nle4, D-Phe7]-α-MSH, amide

[Nle4]-α-MSH, amide

(Nle4,D-Phe7)-α-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647

(Nle4,D-Phe7)-a-MSH

AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647

NLE4, D-PHE7 .ALPHA.-MSH, NDP-MSH, MELANOTAN I

Melanotan Ⅰ Acetate

[Nle4, D-Phe7] α-MSH NDP-MSH Melanotan Ⅰ

[Nle4,D-Phe7] α -MSH NDP-MSH Melanotan I

alpha-melanotropin, [Nle3,D-Phe7], trifluoroacetate

Melanotan II(10mg) /Mt-2 for Tanning Melanotan 2 CAS NO.75921-69-6 CAS NO.75921-69-6

Afamelanotide

[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone (MSH), amide

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt

a-Melanotropin (swine),4-L-norleucine-7-D-phenylalanine-

Afamelanotide acetate

[NLE4, D-PHE7]-ALPHA-MSH, AMIDE

[NLE4,D-PHE7]-ALPHA-MELANOCYTE-STIMULATING HORMONE

[NLE4,DPHE7] ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE

NDP-MSHAC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2

NDP-MSH

Melanotan ① Acetate

[NLE4, DPHE7] A-MSH, AMIDE; MELANOTAN Ⅰ

Melanotan Ⅰ

MELANOTAN I

AC-SYS-NLE-EHFRWGKPV-NH2

AC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2

NLE-4-D-PHE-7-A-MELANOCYTE*STIMULATING H ORMONE

[Nle4,D-Phe7]-MSHNDP-MSH

[Nle4,D-Phe7] a-Melanocyte stimulating hormone,amide

[nle4, d-phe7]-α-melanocyte stimulating hormone trifluoroacetate salt

MSH, 4-Nle-7-Phe-alpha-

Melanotan I Acetate MelanotanⅠ(α-MSH)

4-Nle-7-phe-alpha-msh

4-Norleucyl-7-phenylalanine-alpha-msh

Melanotan-1

Melanotropin

[Nle4, D-Phe7]-α-Melanocyte stimulating hormone trifluoroacetate salt, ≥95% (HPLC)

N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-a-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide

α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-

Melanotan-1 USP/EP/BP

4-L-norleucine-7-D-phenylalanine-α-Melanotropin

Melanotan 1 (MT1) acetate

(Nle4,D-Phe7)-α-MSH

MT I （Melanotan-1）

MT-I (Melanotan I)

Melanotan I (MT1) acetate

[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt

Melanotan I (Afamelanotide

CUV1647)

α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-