ChemicalBook > CAS DataBase List > (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
- Product Name
- (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
- CAS No.
- 300353-13-3
- Chemical Name
- (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
- Synonyms
- Ro 28-1675;Ro 0281675;RO281675,RO 28 1675;RO 028-1675;RO 0281675;RO 28-1675 (Ro 0281675);RO 28-1675 - RO 28-0450, (R)-;(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide;BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
- CBNumber
- CB42516200
- Molecular Formula
- C18H22N2O3S2
- Formula Weight
- 378.51
- MOL File
- 300353-13-3.mol
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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Property
- Density
- 1.306
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)
- form
- Powder
- pka
- 8.65±0.50(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Axon Medchem
- Product number
- Axon1356
- Product name
- RO28-1675-RO28-0450,(R)-
- Purity
- 99%
- Packaging
- 2mg
- Price
- $115.5
- Updated
- 2021/12/16
Axon Medchem
- Product number
- Axon1356
- Product name
- RO28-1675-RO28-0450,(R)-
- Purity
- 99%
- Packaging
- 5mg
- Price
- $159.5
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-2016
- Product name
- RO-28-1675
- Purity
- 99.95%
- Packaging
- 5mg
- Price
- $258
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0004737
- Product name
- (R)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE
- Purity
- 95.00%
- Packaging
- 2MG
- Price
- $262
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-2016
- Product name
- RO-28-1675
- Purity
- 99.95%
- Packaging
- 10mg
- Price
- $444
- Updated
- 2021/12/16
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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Chemical Properties,Usage,Production
Definition
ChEBI: (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(2-thiazolyl)propanamide is a member of acetamides.
Biological Activity
RO-28-1675 is a potent allosteric activator of glucokinase with EC50 of 54 nM. It can be used in type 2 diabetes research.
in vitro
RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).
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in vivo
RO-28-1675 (50 mg/kg; po) reduces blood glucose levels in wild-type C57BL/6J mice.
RO-28-1675 (10 mg/kg; po) displays lower clearance and higher oral bioavailability.
Animal Model: | 10 weeks old male C57BL/6J mice |
Dosage: | 50 mg/kg |
Administration: | Oral administration |
Result: | Reduced blood glucose levels. |
Animal Model: | C57BL/6J mice |
Dosage: td> | 10 mg/kg |
Administration: | Oral administr ation |
Result: | AUC 0-inf (5150 ng? h/mL), C max (1140 μg/mL) , T max (3.3 hours ), F po (92.8%) with 10 mg/kg orally administered. |
target
EC50: 54 nM (glucokinase)
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Preparation Products And Raw materials
Raw materials
Preparation Products
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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Suppliers
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