2,4,6-Trichlorobenzaldehyde
- Product Name
- 2,4,6-Trichlorobenzaldehyde
- CAS No.
- 24473-00-5
- Chemical Name
- 2,4,6-Trichlorobenzaldehyde
- Synonyms
- 2,4,6-Trichlorobenzaldehyde;Benzaldehyde, 2,4,6-trichloro-
- CBNumber
- CB42516361
- Molecular Formula
- C7H3Cl3O
- Formula Weight
- 209.46
- MOL File
- 24473-00-5.mol
2,4,6-Trichlorobenzaldehyde Property
- Melting point:
- 58.5-59.5℃
- Boiling point:
- 180-195℃ (12 Torr)
- Density
- 1.529±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale Yellow
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T774738
- Product name
- 2,4,6-Trichlorobenzaldehyde
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 118354
- Product name
- 2,4,6-Trichlorobenzaldehyde
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- Z4481
- Product name
- 2,4,6-Trichlorobenzaldehyde
- Packaging
- 5g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 2615-5-21
- Product name
- 2,4,6-Trichlorobenzaldehyde
- Packaging
- 1g
- Price
- $292
- Updated
- 2021/12/16
- Product number
- HCH0362622
- Product name
- 2,4,6-TRICHLOROBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.85
- Updated
- 2021/12/16
2,4,6-Trichlorobenzaldehyde Chemical Properties,Usage,Production
Uses
2,4,6-Trichlorobenzaldehyde is used in the synthesis of Pydiflumetofen (P999040).
Synthesis
108-70-3
68-12-2
24473-00-5
2.8.2 Synthesis of 2,4,6-trichlorobenzaldehyde (6b): 1,3,5-trichlorobenzene (1.81 g, 10 mmol) was dissolved in anhydrous tetrahydrofuran (36 mL) under dry conditions and stirred at -78°C. The solution was then dissolved in anhydrous tetrahydrofuran (36 mL). N-butyllithium (1.6 M hexane solution, 6.3 mL, 10 mmol) was slowly added dropwise to the above solution over a period of 0.5 h. The solution gradually changed to a light yellow color. After the dropwise addition was completed, stirring was continued at -78 °C for 0.5 hours. Subsequently, anhydrous N,N-dimethylformamide (1.32 mL, 17 mmol) was slowly added dropwise to the reaction mixture and stirring was continued at -80 °C to obtain a light yellow solution. The reaction system was warmed up to -78 °C and kept for 1.5 hours. Upon completion of the reaction, the reaction was quenched with 3N hydrochloric acid solution (36 mL) while keeping the reaction vial at -78 °C and gradually warmed to room temperature to obtain a colorless solution. The reaction mixture was extracted with ethyl acetate (20 mL x 3) and the organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate solution and brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the white needle-like solid product 6b (1.99 g, 96% yield). The structure of the product was determined by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 500 MHz, CDCl3) δ 10.43 (s, 1H), 7.42 (s, 2H); nuclear magnetic resonance carbon spectroscopy (13C NMR, 125 MHz, CDCl3) δ 187.7, 139.4, 137.8, 130.0, 128.8; and high resolution mass spectroscopy (HRMS. ESI) m/z: C7H4Cl3O [M+H]+ calculated value 208.92, measured value 208.9 for confirmation.
References
[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 12, p. 2995 - 3005
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 11, p. 2869 - 2873
[3] Angew. Chem., 2018, vol. 130, # 11, p. 2919 - 2923,5
[4] Patent: CN108191739, 2018, A. Location in patent: Paragraph 0025; 0026; 0027
[5] Patent: WO2013/30138, 2013, A1. Location in patent: Page/Page column 250; 251
2,4,6-Trichlorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2,4,6-Trichlorobenzaldehyde Suppliers
- Tel
- 400-6009262 15618770481
- Fax
- 021-64823266
- yhx@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2819
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-20958197 20965099
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 1183
- Advantage
- 57
- Tel
- 021-20960837
- Fax
- 021-20960837
- market@aloespharm.com
- Country
- China
- ProdList
- 1302
- Advantage
- 55
- Tel
- 025-85205967 13951876367
- Fax
- 025-85205967
- shengsaichem@163.com
- Country
- China
- ProdList
- 818
- Advantage
- 58
- Tel
- 13120367189
- Fax
- 021-50315529
- mychess007@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 55
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 14995
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 400-106-2016 17800804092
- admin@infsci.com
- Country
- China
- ProdList
- 545
- Advantage
- 55
View Lastest Price from 2,4,6-Trichlorobenzaldehyde manufacturers
- Product
- 2,4,6-Trichlorobenzaldehyde 24473-00-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11