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4-Chlorotoluene

Product Name
4-Chlorotoluene
CAS No.
106-43-4
Chemical Name
4-Chlorotoluene
Synonyms
1-CHLORO-4-METHYLBENZENE;P-CHLOROTOLUENE;chlorotoluenes;1-chloro-4-methyl-benzen;4-CHLORO-1-METHYLBENZENE;UPD;p-ChL;4-Chlortoluol;p-Chlortoluol;4-Chlorotoluen
CBNumber
CB9852675
Molecular Formula
C7H7Cl
Formula Weight
126.58
MOL File
106-43-4.mol
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4-Chlorotoluene Property

Melting point:
6-8 °C(lit.)
Boiling point:
162 °C(lit.)
Density 
1.07 g/mL at 25 °C(lit.)
vapor density 
4.38 (vs air)
vapor pressure 
10 mm Hg ( 45 °C)
refractive index 
n20/D 1.52(lit.)
Flash point:
121 °F
storage temp. 
2-8°C
solubility 
0.040g/l
form 
Liquid
color 
Clear
PH
7.4 (H2O)(saturated aqueous solution)
explosive limit
0.7-12.2%(V)
Water Solubility 
<0.1 g/100 mL at 20 ºC
Merck 
14,2171
BRN 
1903635
Dielectric constant
6.0800000000000001
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
LogP
3.33 at 20℃
CAS DataBase Reference
106-43-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-chloro-4-methyl-(106-43-4)
EPA Substance Registry System
p-Chlorotoluene (106-43-4)
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Safety

Hazard Codes 
Xn,N,T,F
Risk Statements 
20-51/53-39/23/24/25-23/24/25-11-10-43
Safety Statements 
24/25-61-45-36/37-16-7
RIDADR 
UN 2238 3/PG 3
WGK Germany 
2
RTECS 
XS9010000
Hazard Note 
Harmful
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29036990
HS Code 
29337900
Hazardous Substances Data
106-43-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H317May cause an allergic skin reaction

H332Harmful if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
111929
Product name
4-Chlorotoluene
Purity
98%
Packaging
100g
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
111929
Product name
4-Chlorotoluene
Purity
98%
Packaging
500g
Price
$260
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB2502168
Product name
Anti-UROD antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μG
Price
$545
Updated
2023/01/07
TCI Chemical
Product number
C0297
Product name
4-Chlorotoluene
Packaging
25G
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
C0297
Product name
4-Chlorotoluene
Packaging
500G
Price
$72
Updated
2024/03/01
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4-Chlorotoluene Chemical Properties,Usage,Production

Chemical Properties

Colorless oily liquid. Slightly soluble in water. Soluble in ethanol, ether, acetone, benzene and chloroform.

Uses

4-Chlorotoluene is used in a variety of organic synthesis, such as acting as coupling precursors for palladium-catalyzed acylation of acetanilides. It is also used for the preparation model gas of 4-chlorotoulene by passing synthesized air into liquid 4-chlorotoulene.

Preparation

4-Chlorotoluene is obtained from p-toluidine by diazotization and substitution. Add p-toluidine and hydrochloric acid to the reaction pot and stir and heat until dissolved at 60℃, then cool to below 15℃ and add sodium nitrite solution dropwise. After reaching the end point, continue to stir for 0.5h. Add cuprous chloride hydrochloric acid solution and stir at room temperature for 3h. Then raise the temperature to 60℃ and keep for 0.5h, cool to room temperature and leave to stratify, discard the acid water layer, wash with water to neutral, filter and get p-chlorotoluene.

Application

4-chlorotoluene is used as a solvent and intermediate for dyes and other organic chemicals. It is used mainly to produce p-chlorobenzotrichloride, from whichis obtained p-chlorobenzotrifluoride, an important precursor of herbicides (e.g., trifluralin:α,α,α,-trifluoro-2,6-dinitro-N,Ndipropyl-p-toluidine). Other side-chain-chlorinated products or their derivatives are 4- chlorobenzyl chloride (for pharmaceuticals, rice herbicides, and pyrethrin insecticides), 4- chlorobenzaldehyde (for dyes and pharmaceuticals), 4-chlorobenzoyl chloride (for pharmaceuticals and peroxides), and 4-chlorobenzoic acid (for dyes). 4-Chlorotoluene is also a starting material in the synthesis of 2,4- and 3,4-dichlorotoluene and of 4-chlorobenzonitrile. [ChemicalBook]

Definition

ChEBI: 4-Chlorotoluene is a member of monochlorobenzenes. It is an intermediate for the manufacture of Fenvalerate, Paclobutrazol, Uniconazole, Trifluralin,Thiobencarb, Daimuron and other pesticides.

General Description

The reaction of 4-chlorotouleneand phenylboronic acid with Pd(OAc)2/L?2HX as the catalyst is the model reaction for determining the efficiencies of bisimidazolylidene (L) ligand precursors.

Hazard

Avoid inhalation; strong irritant.

Flammability and Explosibility

Flammable

Safety Profile

Moderately toxic by ingestion. Mdly toxic by inhalation. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLYL CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.

Purification Methods

Dry it with BaO, fractionally distil it, then fractionally crystallise it by partial freezing. [Beilstein 5 IV 806.]

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4-Chlorotoluene Suppliers

Qingdao Dexin Chemical Co. LTD
Tel
15624488783
Email
290898708@qq.com
Country
China
ProdList
107
Advantage
58
Shandong Jiuyue Biological Technology Co. LT
Tel
0531-18853316981 18853316981
Email
1214127295@qq.com
Country
China
ProdList
60
Advantage
58
QINGDAO CHENXI NEW ENERGYCO.LTD
Tel
19012836015
Email
cxxny88882022@163.com
Country
China
ProdList
58
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7508
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2883
Advantage
65
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
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View Lastest Price from 4-Chlorotoluene manufacturers

Shanghai Xin Cheng Yue Chemical Co.,Ltd
Product
4-Chlorotoluene 106-43-4
Price
US $0.00-0.00/kg
Min. Order
1000kg
Purity
99.8%
Supply Ability
100000ton
Release date
2024-01-26
Henan Fengda Chemical Co., Ltd
Product
4-Chlorotoluene 106-43-4
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Hebei Yanxi Chemical Co., Ltd.
Product
4-Chlorotoluene 106-43-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-16

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