4-Chlorotoluene
- Product Name
- 4-Chlorotoluene
- CAS No.
- 106-43-4
- Chemical Name
- 4-Chlorotoluene
- Synonyms
- 1-CHLORO-4-METHYLBENZENE;P-CHLOROTOLUENE;chlorotoluenes;4-CHLORO-1-METHYLBENZENE;1-chloro-4-methyl-benzen;UPD;p-ChL;4-Chlortoluol;p-Chlortoluol;4-Chlorotoluen
- CBNumber
- CB9852675
- Molecular Formula
- C7H7Cl
- Formula Weight
- 126.58
- MOL File
- 106-43-4.mol
4-Chlorotoluene Property
- Melting point:
- 6-8 °C(lit.)
- Boiling point:
- 162 °C(lit.)
- Density
- 1.07 g/mL at 25 °C(lit.)
- vapor density
- 4.38 (vs air)
- vapor pressure
- 10 mm Hg ( 45 °C)
- refractive index
- n20/D 1.52(lit.)
- Flash point:
- 121 °F
- storage temp.
- 2-8°C
- solubility
- 0.040g/l
- form
- Liquid
- color
- Clear
- PH
- 7.4 (H2O)(saturated aqueous solution)
- explosive limit
- 0.7-12.2%(V)
- Water Solubility
- <0.1 g/100 mL at 20 ºC
- Merck
- 14,2171
- BRN
- 1903635
- Henry's Law Constant
- 2.7×10-3 mol/(m3Pa) at 25℃, Brockbank (2013)
- Dielectric constant
- 6.0800000000000001
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChI
- 1S/C7H7Cl/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
- InChIKey
- NPDACUSDTOMAMK-UHFFFAOYSA-N
- SMILES
- Cc1ccc(Cl)cc1
- LogP
- 3.33 at 20℃
- CAS DataBase Reference
- 106-43-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1-chloro-4-methyl-(106-43-4)
- EPA Substance Registry System
- p-Chlorotoluene (106-43-4)
Safety
- Hazard Codes
- Xn,N,T,F
- Risk Statements
- 20-51/53-39/23/24/25-23/24/25-11-10-43
- Safety Statements
- 24/25-61-45-36/37-16-7
- RIDADR
- UN 2238 3/PG 3
- WGK Germany
- 2
- RTECS
- XS9010000
- Hazard Note
- Harmful
- TSCA
- TSCA listed
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29036990
- HS Code
- 29337900
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Acute Tox. 4 Inhalation
Aquatic Chronic 2
Flam. Liq. 3
Skin Sens. 1 - Hazardous Substances Data
- 106-43-4(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H303May be harmfulif swallowed
H305May be fatal if swallowed and enters airways
H317May cause an allergic skin reaction
H332Harmful if inhaled
H361Suspected of damaging fertility or the unborn child
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P331Do NOT induce vomiting.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P391Collect spillage. Hazardous to the aquatic environment
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 111929
- Product name
- 4-Chlorotoluene
- Purity
- 98%
- Packaging
- 100g
- Price
- $118
- Updated
- 2026/04/30
- Product number
- 111929
- Product name
- 4-Chlorotoluene
- Purity
- 98%
- Packaging
- 500g
- Price
- $260
- Updated
- 2026/04/30
- Product number
- SAB2502168
- Product name
- Anti-UROD antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100μG
- Price
- $545
- Updated
- 2023/01/07
- Product number
- C0297
- Product name
- 4-Chlorotoluene
- Packaging
- 25G
- Price
- $28
- Updated
- 2026/04/30
- Product number
- C0297
- Product name
- 4-Chlorotoluene
- Packaging
- 500G
- Price
- $72
- Updated
- 2026/04/30
4-Chlorotoluene Chemical Properties,Usage,Production
Chemical Properties
Colorless oily liquid. Slightly soluble in water. Soluble in ethanol, ether, acetone, benzene and chloroform.
Uses
4-Chlorotoluene is used in a variety of organic synthesis, such as acting as coupling precursors for palladium-catalyzed acylation of acetanilides. It is also used for the preparation model gas of 4-chlorotoulene by passing synthesized air into liquid 4-chlorotoulene.
Preparation
4-Chlorotoluene is obtained from p-toluidine by diazotization and substitution. Add p-toluidine and hydrochloric acid to the reaction pot and stir and heat until dissolved at 60℃, then cool to below 15℃ and add sodium nitrite solution dropwise. After reaching the end point, continue to stir for 0.5h. Add cuprous chloride hydrochloric acid solution and stir at room temperature for 3h. Then raise the temperature to 60℃ and keep for 0.5h, cool to room temperature and leave to stratify, discard the acid water layer, wash with water to neutral, filter and get p-chlorotoluene.
Application
4-chlorotoluene is used as a solvent and intermediate for dyes and other organic chemicals. It is used mainly to produce p-chlorobenzotrichloride, from whichis obtained p-chlorobenzotrifluoride, an important precursor of herbicides (e.g., trifluralin:α,α,α,-trifluoro-2,6-dinitro-N,Ndipropyl-p-toluidine). Other side-chain-chlorinated products or their derivatives are 4- chlorobenzyl chloride (for pharmaceuticals, rice herbicides, and pyrethrin insecticides), 4- chlorobenzaldehyde (for dyes and pharmaceuticals), 4-chlorobenzoyl chloride (for pharmaceuticals and peroxides), and 4-chlorobenzoic acid (for dyes). 4-Chlorotoluene is also a starting material in the synthesis of 2,4- and 3,4-dichlorotoluene and of 4-chlorobenzonitrile. [ChemicalBook]
Definition
ChEBI: 4-Chlorotoluene is a member of monochlorobenzenes. It is an intermediate for the manufacture of Fenvalerate, Paclobutrazol, Uniconazole, Trifluralin,Thiobencarb, Daimuron and other pesticides.
General Description
The reaction of 4-chlorotouleneand phenylboronic acid with Pd(OAc)2/L2HX as the catalyst is the model reaction for determining the efficiencies of bisimidazolylidene (L) ligand precursors.
Hazard
Avoid inhalation; strong irritant.
Flammability and Explosibility
Flammable
Safety Profile
Moderately toxic by ingestion. Mdly toxic by inhalation. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLYL CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.
Purification Methods
Dry it with BaO, fractionally distil it, then fractionally crystallise it by partial freezing. [Beilstein 5 IV 806.]
4-Chlorotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chlorotoluene manufacturers
- Product
- 4-Chlorotoluene 106-43-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1000kg
- Purity
- 99.8%
- Supply Ability
- 100000ton
- Release date
- 2024-01-26
- Product
- 4-Chlorotoluene 106-43-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-14
- Product
- 4-Chlorotoluene 106-43-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-16