1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

Product Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
CAS No.: 1216744-19-2
Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Synonyms: SK4112;SR6452;GSK 4112;GSK4112,SR6452;SR6452; SR-6452; SR 6452;tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate;tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate;1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate;Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester;SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112
CBNumber: CB42518693
Molecular Formula: C18H21ClN2O4S
Formula Weight: 396.89
MOL File: 1216744-19-2.mol

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1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Property

Melting point:: 95 - 96°C
Boiling point:: 486.7±45.0 °C(Predicted)
Density: 1.296±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
form: powder
pka: 3.87±0.50(Predicted)
color: off-white to tan

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Safety

Hazard Codes: Xi
Risk Statements: 41-43
Safety Statements: 26-36/37/39
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G0673
Product name: GSK4112
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $174
Updated: 2023/06/20

Sigma-Aldrich

Product number: G0673
Product name: GSK4112
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $557
Updated: 2023/06/20

Cayman Chemical

Product number: 11931
Product name: GSK4112
Purity: ≥98%
Packaging: 5mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 11931
Product name: GSK4112
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 11931
Product name: GSK4112
Purity: ≥98%
Packaging: 25mg
Price: $286
Updated: 2024/03/01

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1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Chemical Properties,Usage,Production

Uses

GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.

Biochem/physiol Actions

GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.

storage

Store at +4°C

1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Suppliers

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View Lastest Price from 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate manufacturers

Career Henan Chemical Co

Product: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate 1216744-19-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

1216744-19-2, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinateRelated Search:

1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

GSK 4112

SR6452

GSK4112,SR6452

tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate

SR6452; SR-6452; SR 6452

tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate

SK4112

Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester

SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112

1216744-19-2

Chelating Agents & Ligands, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds