ChemicalBook > CAS DataBase List > GLYX 13

GLYX 13

Product Name
GLYX 13
CAS No.
117928-94-6
Chemical Name
GLYX 13
Synonyms
GLYX 13;GIYX-13;CS-1640;Rapastinel;TPPT-amide;GLYX 13 TFA;UNII-6A1X56B95E;NRX-1074 GLYX-13;GLYX13(Rapastinel);Rapastinel(GLYX-13)
CBNumber
CB42518800
Molecular Formula
C18H31N5O6
Formula Weight
413.47
MOL File
117928-94-6.mol
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GLYX 13 Property

Boiling point:
844.2±65.0 °C(Predicted)
Density 
1.370±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form 
powder
pka
12.26±0.45(Predicted)
color 
white to tan
Water Solubility 
Soluble to 2 mg/ml in water
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0109
Product name
GLYX-13 trifluoroacetate
Purity
≥98% (HPLC)
Packaging
1mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
21385
Product name
GLYX 13
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
21385
Product name
GLYX 13
Purity
≥98%
Packaging
5mg
Price
$426
Updated
2024/03/01
Tocris
Product number
3406
Product name
GLYX13
Packaging
1
Price
$150
Updated
2021/12/16
TRC
Product number
G650020
Product name
GLYX-13
Packaging
1mg
Price
$60
Updated
2021/12/16
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GLYX 13 Chemical Properties,Usage,Production

Uses

Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.

Uses

GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder.

Uses

GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.

Biochem/physiol Actions

GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.

storage

Store at -20°C

GLYX 13 Preparation Products And Raw materials

Raw materials

Preparation Products

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GLYX 13 Suppliers

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View Lastest Price from GLYX 13 manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
GLYX-13 117928-94-6
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
2000kg
Release date
2024-03-21
Shanghai Getian Industrial Co., LTD
Product
GLYX 13 117928-94-6
Price
US $28.00/box
Min. Order
1box
Purity
99%
Supply Ability
20000
Release date
2024-04-11
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
GLYX-13 117928-94-6
Price
US $0.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-04-16

117928-94-6, GLYX 13Related Search:

Linezolid Teriparatide acetate RESIQUIMOD

  • L-ThreoninaMide, L-threonyl-L-prolyl-L-prolyl-
  • GLYX-13 trifluoroacetate
  • L-Threonyl-L-prolyl-L-prolyl-L-threoninamide trifluoroacetate
  • GLYX 13
  • Thr-Pro-Pro-Thr-NH2 trifluoroacetate
  • TPPT-amide trifluoroacetate
  • Rapastinel
  • GIYX-13
  • L-Threonyl-L-prolyl-L-prolyl-L-threoninamide
  • GLYX-13 trifluoroacetate,Rapastinel
  • GLYX13(Rapastinel)
  • (S)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamide
  • CS-1640
  • GLYX-13;GLYX 13;GLYX13
  • Rapastinel(GLYX-13)
  • UNII-6A1X56B95E
  • Rapastinel,GLYX-13,Thr-Pro-Pro-Thr-NH2, >99%
  • GLYX-13;GLYX13;GLYX 13;THR-PRO-PRO-THR-NH2
  • Thr-Pro-Pro-Thr-NH2
  • TPPT-amide
  • (2s)-1-[(2s)-1-[(2s,3r)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]pyrrolidine-2-carboxamide
  • (S)-1-(L-threonyl-L-prolyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)pyrrolidine-2-carboxamide
  • NRX-1074 GLYX-13
  • Rapastinel (GLYX-13) acetate
  • GLYX 13 TFA
  • 117928-94-6
  • C18H31N5O6