ChemicalBook > CAS DataBase List > GLYX 13
GLYX 13
- Product Name
- GLYX 13
- CAS No.
- 117928-94-6
- Chemical Name
- GLYX 13
- Synonyms
- GLYX 13;GIYX-13;CS-1640;Rapastinel;TPPT-amide;GLYX 13 TFA;UNII-6A1X56B95E;NRX-1074 GLYX-13;GLYX13(Rapastinel);Rapastinel(GLYX-13)
- CBNumber
- CB42518800
- Molecular Formula
- C18H31N5O6
- Formula Weight
- 413.47
- MOL File
- 117928-94-6.mol
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GLYX 13 Property
- Boiling point:
- 844.2±65.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- powder
- pka
- 12.26±0.45(Predicted)
- color
- white to tan
- Water Solubility
- Soluble to 2 mg/ml in water
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Safety
- WGK Germany
- 3
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0109
- Product name
- GLYX-13 trifluoroacetate
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $214
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21385
- Product name
- GLYX 13
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21385
- Product name
- GLYX 13
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $426
- Updated
- 2024/03/01
Tocris
- Product number
- 3406
- Product name
- GLYX13
- Packaging
- 1
- Price
- $150
- Updated
- 2021/12/16
TRC
- Product number
- G650020
- Product name
- GLYX-13
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
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GLYX 13 Chemical Properties,Usage,Production
Uses
Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.
Uses
GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder.
Uses
GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.
Biochem/physiol Actions
GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.
storage
Store at -20°C
GLYX 13 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GLYX 13 manufacturers
Baoji Guokang Bio-Technology Co., Ltd.
- Product
- Rapastinel 117928-94-6
- Price
- US $240.00/g
- Min. Order
- 1g/Bag
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-06-04
Baoji Guokang Bio-Technology Co., Ltd.
- Product
- GLYX 13 117928-94-6
- Price
- US $238.00/g
- Min. Order
- 1g
- Purity
- 95%
- Supply Ability
- 100KG
- Release date
- 2021-06-05
hebei hongtan Biotechnology Co., Ltd
- Product
- GLYX-13 117928-94-6
- Price
- US $30.00/box
- Min. Order
- 1box
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-21