N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

Product Name: N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
CAS No.: 244101-02-8
Chemical Name: N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
Synonyms: CM 9;L-798,106;GW 671021;L798106,L 798106;N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide;(2E)-N-[(5-BroMo-2-Methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylMethyl)phenyl]-2-propenaMide;2-Propenamide, N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-, (2E)-
CBNumber: CB42518855
Molecular Formula: C27H22BrNO4S
Formula Weight: 536.44
MOL File: 244101-02-8.mol

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N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide Property

Density: 1.425±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: powder
pka: 4.26±0.10(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L4545
Product name: L-798106
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $157
Updated: 2024/03/01

Sigma-Aldrich

Product number: L4545
Product name: L-798106
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $620
Updated: 2024/03/01

Cayman Chemical

Product number: 11129
Product name: L-798,106
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 11129
Product name: L-798,106
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 11129
Product name: L-798,106
Purity: ≥95%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

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N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide Chemical Properties,Usage,Production

Uses

L-798106 is a potent and selective prostanoid receptor EP3-selective antagonists. L-798106 has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. L-798106 successfully blocks the actions of sulprostone, an EP3-selective agonist. L-798106 was useful in showing that the vascular contraction effect of PGE2 is due to its prostanoid EP3 agonist activity.

Uses

L-798106, a selective prostanoid receptor EP3 antagonist, is used in prostanoid receptor signaling studies that regulate COX-2 levels and the central excitatory effects of PGE(2) on PVN neurons.

Definition

ChEBI: L-798106 is an N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of o-naphthalen-2-ylcinnamic acid with the sulfonamide group of 5-bromo-2-methoxybenzenesulfonamide. It is a selective antagonist for the prostanoid receptor EP3, a prostaglandin receptor for prostaglandin E2 (PGE2). It has a role as a prostaglandin receptor antagonist. It is a N-sulfonylcarboxamide, a member of bromobenzenes and an aromatic ether.

Biochem/physiol Actions

L-798106 was among the first prostanoid receptor EP3-selective antagonists. It has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. It successfully blocks the actions of sulprostone, an EP3-selective agonist, and it helped show that the vascular contraction effect of PGE2 is due to its prostanoid EP3 agonist activity.

storage

Store at RT

N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide Suppliers

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244101-02-8, N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamideRelated Search:

L-798,106

N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

(2E)-N-[(5-BroMo-2-Methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylMethyl)phenyl]-2-propenaMide

CM 9

GW 671021

2-Propenamide, N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-, (2E)-

L798106,L 798106

244101-02-8

C27H22BrNO4S

Potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively).