ChemicalBook > CAS DataBase List > 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine

5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine

Product Name
5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
CAS No.
40045-50-9
Chemical Name
5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Synonyms
Halicin;SU 3327;JNK Inhibitor XIII;SU3327, 10 mM in DMSO;Nitazoxanide Impurity 4;Pinacolborane Impurity 34;JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem;5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine;5-((5-Nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-amine;2-Amino-5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazole
CBNumber
CB42518901
Molecular Formula
C5H3N5O2S3
Formula Weight
261.3
MOL File
40045-50-9.mol
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5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine Property

Melting point:
160 °C(dec.)
Boiling point:
549.8±42.0 °C(Predicted)
Density 
1.88±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO : 62.5 mg/mL (239.19 mM; Need ultrasonic)
form 
Pale yellow solid
pka
0.65±0.10(Predicted)
color 
Light yellow to Amber to Dark green
InChI
InChI=1S/C5H3N5O2S3/c6-3-8-9-5(14-3)15-4-7-1-2(13-4)10(11)12/h1H,(H2,6,8)
InChIKey
NQQBNZBOOHHVQP-UHFFFAOYSA-N
SMILES
S1C(SC2=NC=C([N+]([O-])=O)S2)=NN=C1N
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420144
Product name
JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem
Packaging
10mg
Price
$139
Updated
2025/07/31
TCI Chemical
Product number
U0173
Product name
SU 3327 [Optimized for Cell Culture]
Packaging
1MG
Price
$81
Updated
2025/07/31
TCI Chemical
Product number
A2940
Product name
2-Amino-5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazole
Purity
>96.0%(HPLC)
Packaging
20mg
Price
$203
Updated
2025/07/31
TCI Chemical
Product number
A2940
Product name
2-Amino-5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazole
Purity
>96.0%(HPLC)
Packaging
100mg
Price
$608
Updated
2025/07/31
Tocris
Product number
3607
Product name
SU3327
Purity
≥99%(HPLC)
Packaging
50
Price
$774
Updated
2021/12/16
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5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine Chemical Properties,Usage,Production

Uses

SU 3327 is a JNK inhibitor.

Definition

ChEBI: Halicin is a member of the class of thiadiazoles that is 1,3,4-thiadiazol-2-amine which is substituted by a (5-nitro-1,3-thiazol-2-yl)sulfanediyl group at position 5. It is a c-Jun N-terminal kinase inhibitor (IC50 = 0.7uM) and exhibits antibacterial properties. It has a role as a c-Jun N-terminal kinase inhibitor and an antibacterial agent. It is a member of thiadiazoles, a member of 1,3-thiazoles, a primary amino compound, a C-nitro compound and an organic sulfide.

in vivo

Halicin (Compound 9; 25 mg/kg; intraperitoneal injection; male BKS.Cg-+Leprdb/+Leprdb/OlaHsd db/db mice) treatment possesses the ability to restore insulin sensitivity in mice models of diabetes[1].
Halicin (Compound 9) has favorable microsomal and plasma stability (T1/2 = 27 min)[1].

Animal Model:Male BKS.Cg-+Leprdb/+Leprdb/OlaHsd db/db mice (11-week-old ) injected with insulin[1]
Dosage:25 mg/kg
Administration:Intraperitoneal injection
Result:Resulted in a statistically significant reduction in blood glucose levels.

storage

Store at RT

5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine Suppliers

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View Lastest Price from 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine manufacturers

Hubei Lidu New Material Technology Co., Ltd
Product
5-[(5-NITRO-2-THIAZOLYL)THIO]-1,3,4THIADIAZOL-2-AMINE 40045-50-9
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
20tons
Release date
2024-09-24

40045-50-9, 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amineRelated Search:

p-Toluidine 4-(alpha-Methylbenzyl)resorcinol N,N-Diethyl-m-toluidine Nitrosylsulfuric acid

  • SU 3327
  • 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine
  • 2-Amino-5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazole
  • 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
  • JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem
  • 1,3,4-Thiadiazol-2-amine, 5-[(5-nitro-2-thiazolyl)thio]-
  • Halicin
  • 5-((5-Nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-amine
  • JNK,Thiadiazole,SU-3327,TNF-α,Inhibitor,inhibit,SU 3327,p38α,SU3327,insulin,phosphorylation,substrate-competitive,JIP,protein-protein,PPI
  • Nitazoxanide Impurity 4
  • Pinacolborane Impurity 34
  • SU3327, 10 mM in DMSO
  • JNK Inhibitor XIII
  • 5-((5-Nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-ylamine
  • 40045-50-9