2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride

Product Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
CAS No.: 864289-85-0
Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
Synonyms: C-021;CCR4 Antagonist;C-021, 10 mM in DMSO;C 021 dihydrochloride;C-021 (CCR4 antagonist);4'-?bipiperidin]?-?1'-?yl-?N-?cycloheptyl-?6;2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine;4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine;2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
CBNumber: CB42518956
Molecular Formula: C27H41N5O2.2HCl
Formula Weight: 541
MOL File: 864289-85-0.mol

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2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Property

storage temp.: Desiccate at RT
solubility: Soluble in DMSO
form: solid
color: Pale yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21885
Product name: CCR4 Antagonist
Purity: ≥98%
Packaging: 1mg
Price: $46
Updated: 2021/12/16

Cayman Chemical

Product number: 21885
Product name: CCR4 Antagonist
Purity: ≥98%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

Tocris

Product number: 3581
Product name: C021dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $229
Updated: 2021/12/16

Tocris

Product number: 3581
Product name: C021dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $961
Updated: 2021/12/16

Usbiological

Product number: 254845
Product name: C 021 dihydrochloride
Packaging: 10mg
Price: $480
Updated: 2021/12/16

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2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Chemical Properties,Usage,Production

Biological Activity

c 021 dihydrochloride is a potent antagonist of ccr4 with ic50 values of 0.039 and 0.14 μm for inhibition of chemotaxis in mouse and human, respectively [1].cc chemokine receptor 4 (ccr4) is a g protein-coupled receptor and is a receptor for the cc chemokines, which play an important role in the development and function of the immune system.c 021 dihydrochloride is a potent ccr4 antagonist. c 021 dihydrochloride potently inhibited functional chemotaxis in mice and human with ic50 values of 0.039 and 0.14 μm, respectively. in the gtpγs-binding assay, c 021 dihydrochloride was active with ic50 value of 0.018 μm [1].treatment mice with azoxymethane (aom), which induced hepatic encephalopathy, aom significantly increased microglia activation and the concentrations of ccl2 in the liver, serum, and cortex. c 021 dihydrochloride reduced liver damage and significantly improved the neurological outcomes. also, c 021 dihydrochloride reduced microglia activation and phosphorylation of erk1/2, and inhibited aom-induced cytokine upregulation [2].

References

[1]. yokoyama k, ishikawa n, igarashi s, et al. potent and orally bioavailable ccr4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. bioorg med chem, 2009, 17(1): 64-73.
[2]. mcmillin m, frampton g, thompson m, et al. neuronal ccl2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. j neuroinflammation, 2014, 11: 121.

2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Suppliers

China 31 United Kingdom 1 United States 5 Global 37

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864289-85-0, 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochlorideRelated Search:

2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride

C 021 dihydrochloride

CCR4 Antagonist

4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy

C-021

4'-?bipiperidin]?-?1'-?yl-?N-?cycloheptyl-?6

2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine

Inhibitor,CCR,inhibit,CC chemokine receptor,CCL22,GTPγS,chemotaxis,CCR4,C-021,C021,C 021

2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine

C-021 (CCR4 antagonist)

C-021, 10 mM in DMSO

864289-85-0

C27H41N5O22HCl