2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
- Product Name
- 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
- CAS No.
- 864289-85-0
- Chemical Name
- 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
- Synonyms
- C-021;CCR4 Antagonist;C-021, 10 mM in DMSO;C 021 dihydrochloride;C-021 (CCR4 antagonist);4'-?bipiperidin]?-?1'-?yl-?N-?cycloheptyl-?6;2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine;4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine;2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
- CBNumber
- CB42518956
- Molecular Formula
- C27H41N5O2.2HCl
- Formula Weight
- 541
- MOL File
- 864289-85-0.mol
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Property
- storage temp.
- Desiccate at RT
- solubility
- Soluble in DMSO
- form
- solid
- color
- Pale yellow
N-Bromosuccinimide Price
- Product number
- 21885
- Product name
- CCR4 Antagonist
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $46
- Updated
- 2021/12/16
- Product number
- 21885
- Product name
- CCR4 Antagonist
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3581
- Product name
- C021dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $229
- Updated
- 2021/12/16
- Product number
- 3581
- Product name
- C021dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $961
- Updated
- 2021/12/16
- Product number
- 254845
- Product name
- C 021 dihydrochloride
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Chemical Properties,Usage,Production
Biological Activity
c 021 dihydrochloride is a potent antagonist of ccr4 with ic50 values of 0.039 and 0.14 μm for inhibition of chemotaxis in mouse and human, respectively [1].cc chemokine receptor 4 (ccr4) is a g protein-coupled receptor and is a receptor for the cc chemokines, which play an important role in the development and function of the immune system.c 021 dihydrochloride is a potent ccr4 antagonist. c 021 dihydrochloride potently inhibited functional chemotaxis in mice and human with ic50 values of 0.039 and 0.14 μm, respectively. in the gtpγs-binding assay, c 021 dihydrochloride was active with ic50 value of 0.018 μm [1].treatment mice with azoxymethane (aom), which induced hepatic encephalopathy, aom significantly increased microglia activation and the concentrations of ccl2 in the liver, serum, and cortex. c 021 dihydrochloride reduced liver damage and significantly improved the neurological outcomes. also, c 021 dihydrochloride reduced microglia activation and phosphorylation of erk1/2, and inhibited aom-induced cytokine upregulation [2].
References
[1]. yokoyama k, ishikawa n, igarashi s, et al. potent and orally bioavailable ccr4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. bioorg med chem, 2009, 17(1): 64-73.
[2]. mcmillin m, frampton g, thompson m, et al. neuronal ccl2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. j neuroinflammation, 2014, 11: 121.
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Suppliers
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- United Kingdom
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