AVE8062A
- Product Name
- AVE8062A
- CAS No.
- 253426-24-3
- Chemical Name
- AVE8062A
- Synonyms
- AC 7700;AVE8062A;Ombrabulin HCl;AC7700 (hydrochloride);AVE8062 (hydrochloride);Ombrabulin (AVE8062) HCl;Ombrabulin (hydrochloride);Ombrabulin (AVE8062) hydrochloride;Ombrabulin hydrochloride >=98% (HPLC);Propanamide, 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-, hydrochloride (1:1), (2S)-
- CBNumber
- CB42522391
- Molecular Formula
- C21H26N2O6.ClH
- Formula Weight
- 438.9
- MOL File
- 253426-24-3.mol
AVE8062A Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble; Ethanol: soluble
- form
- powder
- color
- white to beige
- Water Solubility
- H2O: 20mg/mL, clear
Safety
- RTECS
- TX1404540
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1549
- Product name
- Ombrabulin hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $289
- Updated
- 2025/07/31
- Product number
- SML1549
- Product name
- Ombrabulin hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $95.7
- Updated
- 2022/05/15
- Product number
- CS-5451
- Product name
- Ombrabulinhydrochloride
- Purity
- 99.84%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-5451
- Product name
- Ombrabulinhydrochloride
- Purity
- 99.84%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-5451
- Product name
- Ombrabulinhydrochloride
- Purity
- 99.84%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
AVE8062A Chemical Properties,Usage,Production
Uses
Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
General Description
Ombrabulin is a member of the combretastatin A-4 compound class and is a tubulin-depolymerising tumour vascular-disrupting compound.
Biochem/physiol Actions
Ombrabulin is a synthetic water-soluble combretastatin analog vascular disrupting agent. Ombrabulin is a tubulin polymerization inhibitor. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.
in vivo
Before performing therapy experiments, the tolerability of various doses of Ombrabulin (AVE8062) ranging from 10 to 100 mg/kg is tested given twice weekly via i.v., i.p., or s.c. routes in nude mice (n=3 per group). The i.v. and s.c. routes are not pursued further due to problems with skin or tail vein necrosis. The i.p. route is well tolerated with doses up to 100 mg/kg. Next, preliminary experiments are done to determine the lowest dose for in vivo therapeutic efficacy. Starting 7 days after tumor cell injection, nude mice (n=5 per group) bearing HeyA8 ovarian cancer cells are treated with either vehicle or Ombrabulin 10, 30, 50, and 100 mg/kg twice weekly i.p. for 3 weeks. There is 65% reduction in tumor weight in the 30 mg/kg group compared with the vehicle control group (P<0.02). The 10 mg/kg dose is not effective. The antitumor effects at doses >30 mg/kg are not significantly better; therefore, the 30 mg/kg dose is selected for subsequent therapy experiments[1].
References
[1] Kim TJ, et al. Antitumor and antivascular effects of AVE8062 in ovarian carcinoma. Cancer Res. 2007 Oct 1;67(19):9337-45. DOI:10.1158/0008-5472.CAN-06-4018
AVE8062A Preparation Products And Raw materials
Raw materials
Preparation Products
AVE8062A Suppliers
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5167
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58