Ombrabulin
- Product Name
- Ombrabulin
- CAS No.
- 181816-48-8
- Chemical Name
- Ombrabulin
- Synonyms
- CS-1038;AVE-8062;Ombrabuli;ombrabulin;RPR-258062A.;CS-39-L-Ser.HCl;OMbrabulin(AVE-8062);AVE8062;AC-7700;CS-39-L-SER.HCL;AVE-8062A;AVE-8062;RPR-258062A.;(S,Z)-2-Amino-3-hydroxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)propanamide;AVE8062; AVE8062A; AC7700; AVE-8062; AVE-8062A; AC-7700; AVE 8062; AVE 8062A; AC 7700
- CBNumber
- CB31518525
- Molecular Formula
- C21H26N2O6
- Formula Weight
- 402.44
- MOL File
- 181816-48-8.mol
Ombrabulin Property
- Boiling point:
- 648.1±55.0 °C(Predicted)
- Density
- 1.258
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- pka
- 12.03±0.10(Predicted)
- form
- Oil
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- O633403
- Product name
- Ombrabulin
- Packaging
- 5mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- O633403
- Product name
- Ombrabulin
- Packaging
- 25mg
- Price
- $685
- Updated
- 2021/12/16
- Product number
- orb180893
- Product name
- Ombrabulin
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1283.5
- Updated
- 2021/12/16
- Product number
- orb180893
- Product name
- Ombrabulin
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2245.7
- Updated
- 2021/12/16
- Product number
- orb180893
- Product name
- Ombrabulin
- Purity
- >98%
- Packaging
- 1000mg
- Price
- $4321.4
- Updated
- 2021/12/16
Ombrabulin Chemical Properties,Usage,Production
Uses
Ombrabulin is a vascular disrupting agent that enhances the standard therapies in head and neck squamous cell carcinomas.
in vivo
Before performing therapy experiments, the tolerability of various doses of Ombrabulin (AC-7700) ranging from 10 to 100 mg/kg is tested given twice weekly via i.v., i.p., or s.c. routes in nude mice (n=3 per group). The i.v. and s.c. routes are not pursued further due to problems with skin or tail vein necrosis. The i.p. route is well tolerated with doses up to 100 mg/kg. Next, preliminary experiments are done to determine the lowest dose for in vivo therapeutic efficacy. Starting 7 days after tumor cell injection, nude mice (n=5 per group) bearing HeyA8 ovarian cancer cells are treated with either vehicle or Ombrabulin 10, 30, 50, and 100 mg/kg twice weekly i.p. for 3 weeks. There is 65% reduction in tumor weight in the 30 mg/kg group compared with the vehicle control group (P<0.02). The 10 mg/kg dose is not effective. The antitumor effects at doses >30 mg/kg are not significantly better; therefore, the 30 mg/kg dose is selected for subsequent therapy experiments[1].
Ombrabulin Preparation Products And Raw materials
Raw materials
Preparation Products
Ombrabulin Suppliers
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View Lastest Price from Ombrabulin manufacturers
- Product
- Ombrabulin 181816-48-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-14