Plinabulin(NPI-2358)

Product Name: Plinabulin(NPI-2358)
CAS No.: 714272-27-2
Chemical Name: Plinabulin(NPI-2358)
Synonyms: CS-829;NPI-2358;EOS-62083;NSC406141;Plinabulin;NSC 406141;NSC-406141;Plinabulin, >=98%;NPI-2358; NPI 2358;Plinabulin(NPI-2358)
CBNumber: CB92490824
Molecular Formula: C19H20N4O2
Formula Weight: 336.39
MOL File: 714272-27-2.mol

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Plinabulin(NPI-2358) Property

Density: 1.267
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24190
Product name: Plinabulin
Purity: ≥98%
Packaging: 5mg
Price: $160
Updated: 2024/03/01

Cayman Chemical

Product number: 24190
Product name: Plinabulin
Purity: ≥98%
Packaging: 10mg
Price: $263
Updated: 2024/03/01

Cayman Chemical

Product number: 24190
Product name: Plinabulin
Purity: ≥98%
Packaging: 25mg
Price: $547
Updated: 2024/03/01

Cayman Chemical

Product number: 24190
Product name: Plinabulin
Purity: ≥98%
Packaging: 50mg
Price: $911
Updated: 2024/03/01

ApexBio Technology

Product number: B2298
Product name: Plinabulin(NPI-2358)
Packaging: 50mg
Price: $1126
Updated: 2021/12/16

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Plinabulin(NPI-2358) Chemical Properties,Usage,Production

Definition

ChEBI: Plinabulin is a member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione substituted by benzylidene and (5-tert-butyl-1H-imidazol-4-yl)methylidene groups at positions 3 and 6, respectively. It is a vascular disrupting agent and a microtubule destabalising agent which was in clinical trials (now discontinued) for the treatment of non-small cell lung cancer. It has a role as a microtubule-destabilising agent, an antineoplastic agent, an apoptosis inducer and an angiogenesis inhibitor. It is a member of 2,5-diketopiperazines, a member of imidazoles, a member of benzenes and an olefinic compound.

Biological Activity

the ic50 values of npi-2358 is 9.8 ± 2.4 nmol/l, 18 ± 5 nmol/l, 13 ± 1 nmol/l, 14 ± 2 nmol/l, 18 ± 1 nmol/l and 11 nmol/l for ht-29, du 145, pc-3, mda-mb-231, ncl-h292 and jurkat cell lines, respectively[1].plinabulin (npi-2358) is a vascular disrupting agent which binds to the colchicine-binding site of tubulin. npi-2358 could destabilize tumor vascular endothelial architectural resulting in selective collapse of established tumor vasculature [1].

in vitro

npi-2358 exhibited anti-tumor activity against various human tumor cell lines. in proliferating human umbilical vein endothelial cells (huvecs), administration of npi-2358 at 10 nmol/l induced tubulin depolymerization within 30 min [1]. in an in-vitro model of tumor vascular collapse, npi-2358 increased huvec monolayer permeability in a dose-dependent manner. plinabulin had also shown the in-vitro cytotoxic activity with ic50 values of 11 ± 5 nmol/l and 4.3 ± 2.2 nmol/l for mes-sa and hl-60 tumor cell lines, respectively[1].

in vivo

in the foot implanted c3h mammary carcinomas or leg implanted kht sarcomas mice model, 7.5 mg/kg plinabulin (intraperitoneally injected) significantly reduced the transfer constant (k(trans)) and the initial area under curve (iauc) within 1 hour after injection, reaching a lowest point at 3 h, but returning to normal within 24 h. a dose-dependent decrease in iauc and k(trans) was seen at 3 h. 12.5 mg/kg and 1.5 mg/kg npi-2358 showed significant anti-tumour effects in the c3h tumours and the kht sarcoma, respectively .

target

Tubulin

References

nicholson b1, lloyd gk, miller br, palladino ma, kiso y, hayashi y, neuteboom st. npi-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.anticancer drugs. 2006 jan; 17(1):25-31.bertelsen l b, shen y y, nielsen t, et al. vascular effects of plinabulin (npi-2358) and the influence on tumour response when given alone or combined with radiation[j]. international journal of radiation biology, 2011, 87(11): 1126-1134.millward m, mainwaring p, mita a, et al. phase 1 study of the novel vascular disrupting agent plinabulin (npi-2358) and docetaxel[j]. investigational new drugs, 2012, 30(3): 1065-1073.

Plinabulin(NPI-2358) Preparation Products And Raw materials

Raw materials

Preparation Products

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Plinabulin(NPI-2358) Suppliers

China 87 France 1 India 1 United Kingdom 1 United States 12 Global 102

Shanghai Boyle Chemical Co., Ltd.

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View Lastest Price from Plinabulin(NPI-2358) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Plinabulin 714272-27-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Plinabulin 714272-27-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: Plinabulin(NPI-2358) 714272-27-2
Price: US $1.00/g
Min. Order: 100drums
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

714272-27-2, Plinabulin(NPI-2358)Related Search:

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Plinabulin(NPI-2358)

NPI-2358

Plinabulin

(3Z,6Z)-3-[(5-tert-Butyl-1H-imidazol-4-yl)methylene]-6-(phenylmethylene)-2,5-piperazinedione

NPI-2358 (Plinabulin)

(3Z,6Z)-3-benzylidene-6-((5-tert-butyl-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

(3Z,6Z)-3-[(5-tert-Butyl-1H-imidazol-4-yl)methylene]-6-(phenylmethylene)-2,5-piperazinedione Plinabulin (NPI-2358)

Plinabulin (3Z,6Z)-3-[(5-tert-Butyl-1H-imidazol-4-yl)methylene]-6-(phenylmethylene)-2,5-piperazinedione

Plinabulin, >=98%

3-(Z)-benzylidene-6-(((Z)-5-tert-butyl-1H-imidazol-4-yl)methylene)-piperazine-2,5-dione monohydrate

2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-, (3Z,6Z)-

(Z)-3-((Z)-benzylidene)-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

EOS-62083

NPI-2358; NPI 2358

CS-829

(3Z，6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2，5-dione

Plinabulin(NPI-2358)USP/EP/BP

NSC 406141

NSC406141

NSC-406141

Plinabulin NPI-2358 NPI2358

714272-27-2

714272-27-3

714272-27-4

APIs

Inhibitors