6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one
- Product Name
- 6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one
- CAS No.
- 328956-38-3
- Chemical Name
- 6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one
- Synonyms
- 6-Nitro-4-trifluoromethyl-1H-quinolin-2-one;6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one;6-Nitro-4-(trifluoromethyl)-2(1H)-quinolinone;2(1H)-Quinolinone, 6-nitro-4-(trifluoromethyl)-;6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one ISO 9001：2015 REACH
- CBNumber
- CB42524971
- Molecular Formula
- C10H5F3N2O3
- Formula Weight
- 258.15
- MOL File
- 328956-38-3.mol
6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Property
- Melting point:
- 284-285 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 368.7±42.0 °C(Predicted)
- Density
- 1.564±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.09±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0368147
- Product name
- 6-NITRO-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.11
- Updated
- 2021/12/16
- Product number
- 3728AB
- Product name
- 6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one
- Packaging
- 100mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- BB20-6665A
- Product name
- 6-Nitro-4-trifluoromethyl-1H-quinolin-2-one
- Purity
- ＞97%
- Packaging
- 0.5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- A281637
- Product name
- 6-Nitro-4-(trifluoromethyl)quinolin-2(1H)-one
- Purity
- 97%
- Packaging
- 25g
- Price
- $245
- Updated
- 2021/12/16
- Product number
- CM125023
- Product name
- 6-nitro-4-(trifluoromethyl)quinolin-2(3H)-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $251
- Updated
- 2021/12/16
6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Chemical Properties,Usage,Production
Uses
6-Nitro-4-(trifluoromethyl)-2(1H)-quinolinone is an intermediate in the synthesis of LGD-2226 (L397615), an orally active potent and selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Show to have an anabolic effect on muscle and bone tissue.
Synthesis
6-Nitro-4-trifluoromethylquinolin-2(1H)-one is obtained by nitration with 4-Trifluoromethylquinolin-2(1H)-one.
Experimental Procedure：A milky suspension of 33.0 g 4-Trifluoromethylquinolin-2(1H)-one in 200 mL H2SO4 was cooled in an ice-salt bath to -5°C. 14.3 g
70% HNO3 was added dropwise, keeping the internal temperature below 7°C. After addition
was complete, the mixture was stirred at 0-10°C for 1 h and then after removal of the ice bath
the temperature raised to room temperature within the next hours. The yellow solution was then
poured onto 600 g crushed ice and kept standing/stirring for the next 12 h. The resulting two
phases were separated and the organic phase equals a yellow slurry, which was filtered by
suction. The resulting solid was washed with water and dried under vacuum. After
crystallization of 20 g crude product in 1 L ethanol a nearly colorless solid (6-Nitro-4-trifluoromethylquinolin-2(1H)-one) (43%) was
obtained.
6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
6-nitro-4-(trifluoromethyl)quinolin-2(1H)-one Suppliers
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